ID   Q5CQV8_CRYPI            Unreviewed;      1631 AA.
AC   Q5CQV8;
DT   12-APR-2005, integrated into UniProtKB/TrEMBL.
DT   12-APR-2005, sequence version 1.
DT   22-FEB-2023, entry version 80.
DE   RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN   ORFNames=cgd4_3100 {ECO:0000313|EMBL:EAK87803.1};
OS   Cryptosporidium parvum (strain Iowa II).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX   NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK87803.1, ECO:0000313|Proteomes:UP000006726};
RN   [1] {ECO:0000313|EMBL:EAK87803.1, ECO:0000313|Proteomes:UP000006726}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX   PubMed=15044751; DOI=10.1126/science.1094786;
RA   Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA   Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA   Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA   Anantharaman V., Aravind L., Kapur V.;
RT   "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL   Science 304:441-445(2004).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAK87803.1}.
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DR   EMBL; AAEE01000008; EAK87803.1; -; Genomic_DNA.
DR   RefSeq; XP_625894.1; XM_625894.1.
DR   STRING; 353152.Q5CQV8; -.
DR   EnsemblProtists; EAK87803; EAK87803; cgd4_3100.
DR   GeneID; 3372791; -.
DR   KEGG; cpv:cgd4_3100; -.
DR   VEuPathDB; CryptoDB:cgd4_3100; -.
DR   InParanoid; Q5CQV8; -.
DR   OMA; THDRCEN; -.
DR   OrthoDB; 3076794at2759; -.
DR   Proteomes; UP000006726; Chromosome 4.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR47455; ADENYLYL CYCLASE BETA; 1.
DR   PANTHER; PTHR47455:SF1; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006726}.
FT   DOMAIN          123..182
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          425..557
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          224..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          606..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          918..937
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1567..1607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        923..937
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1631 AA;  183034 MW;  F08D3BFF1C90D49C CRC64;
     MGQVPLIAAK STLFVYSGIR SIVVGNKEKV VPQRPPDLDI IASGERDRIS DDWRWLALKS
     EKRLNNMKKM NSSSEQLKKK LGSTFDINQF SCFVPRTVLE AIADKRIGYA DDFDVIIESF
     KGAIMFCDAS GFTALTAALD KQLNGAERLG ECINNFFTPL IQIIHYWGGD VIKFSGDAIC
     VVWPVDDESI NLNNGGVNLI TESTNSSSQA NASECNPQFN KLARDSSKFS NKSKVSIDDN
     SPATSEKRWN KEEQLESEES PSQYSSNAAD TYSVDMFHAC RLACECCMDI HRTLHNFPTP
     IPGRHLTLHI GVGYGRTTIL QVGGVMDRWE YVVGGPPFEE IAIAEPLAKS GETVISPSVF
     SILGKHVSVE PCEGNPDFKK LNSLLLPRPP PPPPLASIHI HDEDVDLLRR YIPPPVYRCL
     SSGYNVFLNE VRRLTCIFVS VKGLDISTHY GSKTAHQLMQ LVQKAAYTME GSVNKFLVDD
     KGVLLLIIFG LPPVYHLDDP LRAVFAGLRI LDSIRFMGLS SSIGIGTGRV WIGTVGCEIR
     KEYTALGDTV NLSARLMARA GENEILCDLN TYEACNHAMQ FIQKESFYPK GKDVSIDTFS
     PTGILTRSRL QGSTGGKAET GNPEDSNLSN NKDNSNIKDG LSTDNLLTTE NSNNQNTDIN
     LNIENLQSIR TWRGWKPLKK LKKFFKPRYS YGLPDMNGPN FRVIPDYAME SMPESKFLGP
     LMPWEYYEPW DPILRPTLDL GGVMTIYGKE NCGIDEIIQN IVHLGEKLER KVFLCSNMPD
     TPFINIGNVP LLPWKTLCTD IVESWRLTKS REKKGFSNID RDNSIYGLAK ELTHPSFHWT
     LHKLKPVLQG LVLPSELSEN KAFLRMGKYK NKESKKMKDI FRNPLLFVKN LNGQPESLDK
     ELDGGELEND ENLNKEVFKD EADDDITSSD EDLSDEDEKG LGPIITSLVN GFSMYENSII
     CLHVKSGTCF YAGMEQESWK IAKMIARIAM IRRKRKVEHD FKELKKWRRK HSRICLFCKG
     FKRPIQHISK DTLYLYKTTK CTPPAFKSSP PLLFILICSS NTDSIEEQKE IIQWAKECNA
     FIEVPKLTLN ETSKFIGHQL GVNTQVPFQL VEYVHRASGG IPEHIKRTLL QLLSHKAISI
     STQDDQQMED PEKKGSLILD SDKSLNNPDS LSNNISRNAS VCSNALSGID SIGNNFDFGA
     ITSIVPGYNL KNIQGDLGFI SSVYSSSDES SSSGSSSSDD SKEWSDDSIK RKIRVPRFRT
     PGPRELLSSD GVPIIGNKQS NRFSSNDLSG SRHRSSFTKF GQSSYLSRNS EDNRRYIKVT
     GQLRKIPFAH EIVAECMSKL ELLEPDEQMA AKIASAFTFA FTASELHEVY PQKKSPLEFL
     KMIKAMVNKD VFEVCDTINF GVDRSRRGSI NSDHNSKHIT LYENDQEKNI NGYEDDIYKD
     ISSSTPIMKD ISDYLSNVNL SDFSKNNKDS IDVTDPCSSE NSEIKNERNE INNDQSVNIN
     IIITEDNQSA SENEFPKPQN CDILPYYIEY YRFQNVAFQR VVSESLLSDE RKRLARISRK
     TLSRRLSKLS PSVRSASPQL PSSPTDSSSS KFADNSEANK ASTRYLSTIP NNVSVNNTIS
     TNLDVLPEDE K
//