ID Q5CUC5_CRYPI Unreviewed; 664 AA.
AC Q5CUC5;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=ATP-dependent RNA helicase {ECO:0000256|RuleBase:RU365068};
DE EC=3.6.4.13 {ECO:0000256|RuleBase:RU365068};
DE Flags: Fragment;
GN ORFNames=cgd3_3380 {ECO:0000313|EMBL:EAK89255.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK89255.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK89255.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- FUNCTION: RNA helicase. {ECO:0000256|RuleBase:RU365068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|RuleBase:RU365068};
CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC family of RNA helicases and controls ATP binding and hydrolysis.
CC {ECO:0000256|RuleBase:RU365068}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC {ECO:0000256|RuleBase:RU365068}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK89255.1}.
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DR EMBL; AAEE01000004; EAK89255.1; -; Genomic_DNA.
DR RefSeq; XP_626889.1; XM_626889.1.
DR AlphaFoldDB; Q5CUC5; -.
DR STRING; 353152.Q5CUC5; -.
DR EnsemblProtists; EAK89255; EAK89255; cgd3_3380.
DR GeneID; 3373940; -.
DR KEGG; cpv:cgd3_3380; -.
DR InParanoid; Q5CUC5; -.
DR OMA; GDIDRCY; -.
DR OrthoDB; 227126at2759; -.
DR Proteomes; UP000006726; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24031:SF96; ATP-DEPENDENT RNA HELICASE DDX56-RELATED; 1.
DR PANTHER; PTHR24031; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365068};
KW Helicase {ECO:0000256|RuleBase:RU365068, ECO:0000313|EMBL:EAK89255.1};
KW Hydrolase {ECO:0000256|RuleBase:RU365068};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365068};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW RNA-binding {ECO:0000256|RuleBase:RU365068}.
FT DOMAIN 48..234
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 278..441
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAK89255.1"
SQ SEQUENCE 664 AA; 75549 MW; 8CC40F1D495DB2E6 CRC64;
KQTMKNENDS NELLSFSELY GSILDRRIIQ SLTNSNYLVP TKVQVEVIKK IIEGKDLLIN
SYTGSGKTLA YAIPICHNLL NISNRLANKV YSLVLVPSRE LVIQTHEIFE QLLVFCENNV
SVGTIFNADD NLLHKGKDLK YGSFRYNILI STPGDILCAK GMGSKESIFQ NIAHLVIDEA
DLLFAFGYDK DMSKVLDLLP NSQDRKYQCI LLSATLNKEV DSLKKMVLHR PIFVDIKPEI
KEDYFDQEGN DSKCQTSGLL SEYYTICDSM VDKWLMLYIL LKMNVIPRKC LIFVSEVDTA
YSIKLFLERF GMSCGVLTPI IPAATRRMLI QCFNQGSYDI LVTSDTINEK DESVLSILKD
NSITYRGVDY KEVASVFNFD CPSSVRSYIH HIGRTARGGS SGVSITIVNS NIPNEMEVLD
ELLNDSNRKM NKLKITSEEV ACFRYRIEDC MRILTKGNIQ RHKLQEIQGL ILNNTRLLKS
GYFSKHPGDK NVLKSYHKHI TNALNISNSG REHIKNIPDY LYDMVNNNIS NSPDFVLDQS
SMPNVSMDSV LSNTNNSSHG GSLTEKVQEA IRRMGAKDFQ FVKENNLNPT NVNKTGNLNS
GKKRIISRKS QLKKEPKSYE GTVPDELPAI SGRKLWKLKH KKRVKKYKDF IDDNKYRKKR
GVRR
//
