ID Q5CWL8_CRYPI Unreviewed; 921 AA.
AC Q5CWL8;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025};
GN ORFNames=cgd6_4550 {ECO:0000313|EMBL:EAK90046.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK90046.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK90046.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707,
CC ECO:0000256|RuleBase:RU366025};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085, ECO:0000256|RuleBase:RU366025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK90046.1}.
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DR EMBL; AAEE01000002; EAK90046.1; -; Genomic_DNA.
DR RefSeq; XP_627786.1; XM_627786.1.
DR AlphaFoldDB; Q5CWL8; -.
DR STRING; 353152.Q5CWL8; -.
DR EnsemblProtists; EAK90046; EAK90046; cgd6_4550.
DR GeneID; 3375791; -.
DR KEGG; cpv:cgd6_4550; -.
DR VEuPathDB; CryptoDB:cgd6_4550; -.
DR InParanoid; Q5CWL8; -.
DR OMA; KVKYKTR; -.
DR OrthoDB; 166948at2759; -.
DR Proteomes; UP000006726; Chromosome 6.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02658; Peptidase_C19B; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR016652; Ubiquitinyl_hydrolase.
DR InterPro; IPR041432; UBP13_Znf-UBP_var.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF10; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR Pfam; PF17807; zf-UBP_var; 1.
DR PIRSF; PIRSF016308; UBP; 1.
DR SMART; SM00290; ZnF_UBP; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU366025};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR016308-3}; Protease {ECO:0000256|RuleBase:RU366025};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Thiol protease {ECO:0000256|RuleBase:RU366025};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU366025};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR016308-3};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00502}.
FT DOMAIN 161..279
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
FT DOMAIN 331..920
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT DOMAIN 691..732
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 549..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 340
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR016308-1"
FT ACT_SITE 861
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR016308-1"
FT BINDING 185
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR016308-3"
FT BINDING 188
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR016308-3"
FT BINDING 205
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR016308-3"
SQ SEQUENCE 921 AA; 104508 MW; 9447C853FF572F67 CRC64;
MNELFEEYLK LIGSKIERKD PVYKAQCQLS FKDSFSEGGL YVNLKNFEAY SRDFLEWDYS
QSGCRLYLSI KGTRKYHPEN IDNPTNLSIG KEGGYFPEKP FFEDLFQYGL VSFPDMEVME
LTDSRVHKEL SERLNYIIQY DQNMELSKDT DSLVAWAEER KVSRHAENLF QVSSPKQISP
KGWTCETCGA STNLWLNLSD GFIGCGRRLY GVGGGCFDGK DEGAALLHYQ QHTERPLAVK
LGTITQFGNA DVFSYDPQED DLVLDPHLVK HLSVFGINVG QLEKTEKSLT EMQIEQNNKL
DLTSGTESEE CGSFLPMNKL FKKGDLLTAL VGLENSGNSC YVNVVLQLLA SIPEVGELFS
IHFQDLLEIY SKYFIQKTRP RESIVIQFSK VIKALLTNDV INDRNYKISS RSKDIQKAIS
ELKEKGINEN IIESLTESEV NPCLVHILPS ILKRTISKGN PEFSSSHQQD TLEYFTFLQE
KLSDDLKKYY NHSSQEIQKL IQQFINLFSF FIGERLECKQ TGSVKLTSQL NNVLSLPIPK
DLITYSSDTR QTKKPKHAFG EDGEDLATPK SNHLKEQDMN DDHECFSDIS LLLSNWRQEE
IVESFLSPCT NQLGKAGKSN FIKSMPKYLI IHMQRFYLSE DWRPKKINLS VKVPNFLDLE
SLRDSEELKP GEKPFPEGVD EVNKSLKEEV QVPESLVNSV LDLGFTKSHA ELAVKNTFST
DIDICINWIL TNIDSINSMD LTSSDSSSSS SSSSASNTSK TNNSASHQDL EAIENIISIC
CCSRDIAEKA FKISNQNLER AIQMIFDDPS IIESFEDTQL QQQVSVGPDL SSKLIELDDG
PGKYELIGVI CHLGKSVHSG HYICYNKRKI DSSINPSNQP TESSCSSSIW VRFNDTKVYL
SKEDDFPHKE KGYIYLYRRT N
//