ID Q5DTS7_MOUSE Unreviewed; 422 AA.
AC Q5DTS7;
DT 29-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 29-MAR-2005, sequence version 1.
DT 22-FEB-2023, entry version 64.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE Flags: Fragment;
GN Name=Adcy4 {ECO:0000313|MGI:MGI:99674};
GN Synonyms=mKIAA4004 {ECO:0000313|EMBL:BAD90272.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAD90272.1};
RN [1] {ECO:0000313|EMBL:BAD90272.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Fetal brain {ECO:0000313|EMBL:BAD90272.1};
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the Coding Sequences of Mouse Homologues of KIAA Gene. The
RT Complete Nucleotide Sequences of Mouse KIAA-homologous cDNAs Identified by
RT Screening of Terminal sequences of cDNA Clones Randomly Sampled from Size-
RT Fractionated Libraries..";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AK220443; BAD90272.1; -; mRNA.
DR AlphaFoldDB; Q5DTS7; -.
DR PeptideAtlas; Q5DTS7; -.
DR AGR; MGI:99674; -.
DR MGI; MGI:99674; Adcy4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR032628; AC_N.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF10; ADENYLATE CYCLASE TYPE 4; 1.
DR Pfam; PF16214; AC_N; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 306..387
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAD90272.1"
SQ SEQUENCE 422 AA; 47287 MW; D4B209EDD488E066 CRC64;
KTMARLFSPR PPPSEDLFYE TYYSLSQQYP LLILLLVIVL CALVALPAVA WASGRELTSD
PSFLTTVLCA LGGFSLLLGL ASREQQLQRW TRPLSGLIWV ALLALGYGFL FTGGVVSAWD
QVRKIKAWGK VNLKFRPWAQ HHGHSASHTL LQVSFFLFII FTVYAMLPLG MRDAAAAGVI
SSLSHLLVLG LYLGWQPESQ RALLPQLAAN AVLFLCGNVV GAYHKALMER ALRATFREAL
SSLHSRRRLD TEKKHQEHLL LSILPAYLAR EMKAEIMARL QAGQRSRPEN TNNFHSLYVK
RHQGVSVLYA DIVGFTRLAS ECSPKELVLM LNELFGKFDQ IAKEHECMRI KILGDCYYCV
SGLPLSLPDH AINCVRMGLD MCRAIRSALV CEQEKLRAPG VGEGVREAGW QSSWRRGESW
QH
//
