ID   Q5FLU2_LACAC            Unreviewed;       864 AA.
AC   Q5FLU2;
DT   01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2005, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=Phage related helicase {ECO:0000313|EMBL:AAV42332.1};
GN   OrderedLocusNames=LBA0442 {ECO:0000313|EMBL:AAV42332.1};
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621 {ECO:0000313|Proteomes:UP000006381};
RN   [1] {ECO:0000313|EMBL:AAV42332.1, ECO:0000313|Proteomes:UP000006381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM
RC   {ECO:0000313|Proteomes:UP000006381};
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000033; AAV42332.1; -; Genomic_DNA.
DR   RefSeq; YP_193363.1; NC_006814.3.
DR   AlphaFoldDB; Q5FLU2; -.
DR   STRING; 272621.LBA0442; -.
DR   REBASE; 28091; LacNCFMORF442P.
DR   KEGG; lac:LBA0442; -.
DR   PATRIC; fig|272621.13.peg.427; -.
DR   eggNOG; COG1061; Bacteria.
DR   eggNOG; COG3886; Bacteria.
DR   HOGENOM; CLU_005588_1_0_9; -.
DR   OrthoDB; 9802848at2; -.
DR   BioCyc; LACI272621:G1G49-456-MONOMER; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd18032; DEXHc_RE_I_III_res; 1.
DR   CDD; cd09204; PLDc_N_DEXD_b2; 1.
DR   CDD; cd18799; SF2_C_EcoAI-like; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR021835; DUF3427.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025202; PLD-like_dom.
DR   PANTHER; PTHR47396:SF1; ATP-DEPENDENT HELICASE IRC3-RELATED; 1.
DR   PANTHER; PTHR47396; TYPE I RESTRICTION ENZYME ECOKI R PROTEIN; 1.
DR   Pfam; PF11907; DUF3427; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF13091; PLDc_2; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:AAV42332.1};
KW   Helicase {ECO:0000313|EMBL:AAV42332.1};
KW   Hydrolase {ECO:0000313|EMBL:AAV42332.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:AAV42332.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006381}.
FT   DOMAIN          236..389
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          440..592
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   864 AA;  100583 MW;  DF0F545AFF274BC0 CRC64;
     MNLEKELTTT VLNNYIDKDR FLSTGNLSAR LILNHNQNDN VYRVLKMELA TCKSFTFAVA
     FITQRGFTSF LTILSDLAKR GIHGRVLTST YLYFNEPEAF RSLLKVPNIE TRIFNERDLE
     TDKELPFHAK GYLFEHEGYR TAIIGSSNLT SGALISNYEW NLNVNSSDNA EITEQINWQI
     EDEWRKATPL TEKWLTWYQY QFERNKPVDP QIAENKSKLK VQPNKMQKEA LGEIQSLRQN
     GKNKALIISA TGTGKTYLGA FDVQKFKPKR FLYVVHREQI LQKSRNSFYD VIGGAYSDYG
     IYSGNHREGL KSKYIFATVQ TLAKDENLKK FARDAFDYIL FDEAHHLGSV QELKIFNYFQ
     PQFCLGMTAT PERTDDFNIY KLFDYNIAYE IRLQNALDQD MLCPFHYYGV EDYIYQDELI
     NGATSLKRLV SDERVNYILQ QTDYYGYSGR TLHGLIFCSR KKEAEILAEK LTEKGCPALA
     ISGTDSIGER EKAVKKLEKG KVKYIVTVDV FNEGVDIPCI NQIVLLRNTQ SSIVFVQQLG
     RGLRKYKGKD YLTVIDFVGN YDNNYLIPVA LTGDKSHNRD QVRDKLDLEP IYGVSLINFT
     NVAKSQIYKS INHSNLTLKR KLREEYINEK RKIGRVPLMY DLQNESIDCE VIAEKYKNYS
     HFLQEMGETE YQVSNFQNKI LEFLTVVLAN GKRKHELLLL DMLLEQNKVK EYEYLAILKE
     NHCLISNNIL KSVDEILSLS FFIRKSLPNK VTYGGESIVE HKNKKYFLNE KVRKELRDKN
     FYTLFRDAIK TGLLRSKKYD SDKIFTINER YTRMDANRLL NWDKIVPGQN IGGYKFDYDK
     KNCAIFITYN KKNDALAYQD RFIN
//