UniProt: Q5H736

Database: UniProt
Entry: Q5H736_STAAU

LinkDB:  Q5H736_STAAU 
Original site:  Q5H736_STAAU

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Ontology (6)   
   GO (6)   
Gene (2)   
   KEGG GENES (2)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (20)   
   EMBL (20)   
Protein domain (16)   
   InterPro (10)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
Literature (2)   
   PubMed (2)   
All databases (47)   

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ID   Q5H736_STAAU            Unreviewed;       453 AA.
AC   Q5H736; A0A0D1HKS5; A0A1E8XFB2;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 147.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|ARBA:ARBA00018893, ECO:0000256|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:BAD89355.1};
GN   ORFNames=DD547_00020 {ECO:0000313|EMBL:AXP69914.1}, EP54_05540
GN   {ECO:0000313|EMBL:KMR57610.1}, EQ90_05830
GN   {ECO:0000313|EMBL:KMR37007.1}, G6W63_04855
GN   {ECO:0000313|EMBL:NGW87020.1}, G6Y24_09790
GN   {ECO:0000313|EMBL:NGW67785.1}, GO782_01805
GN   {ECO:0000313|EMBL:MVH47371.1}, GO814_09890
GN   {ECO:0000313|EMBL:MVK35447.1}, GO852_11860
GN   {ECO:0000313|EMBL:MVK03616.1}, GO942_12190
GN   {ECO:0000313|EMBL:MVM11424.1}, GZ067_09695
GN   {ECO:0000313|EMBL:QID97902.1}, GZ156_07985
GN   {ECO:0000313|EMBL:NDQ60471.1}, HMPREF3211_01017
GN   {ECO:0000313|EMBL:KXA37244.1}, M1K003_1447
GN   {ECO:0000313|EMBL:GBV20456.1}, NCTC7972_01915
GN   {ECO:0000313|EMBL:SUK18367.1}, QU38_15530
GN   {ECO:0000313|EMBL:KIT95315.1}, SA0759_00001
GN   {ECO:0000313|EMBL:QLH96774.1}, SA950122_00001
GN   {ECO:0000313|EMBL:QLH99421.1}, SAJPND4_00001
GN   {ECO:0000313|EMBL:BAR10237.1}, SAMEA70153168_00978
GN   {ECO:0000313|EMBL:CAC8226357.1};
OS   Staphylococcus aureus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:BAD89355.1};
RN   [1] {ECO:0000313|EMBL:BAD89355.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RN4220 {ECO:0000313|EMBL:BAD89355.1};
RX   PubMed=16451174; DOI=10.1111/j.1574-6968.2005.00012.x;
RA   Murai N., Kurokawa K., Ichihashi N., Matsuo M., Sekimizu K.;
RT   "Isolation of a temperature-sensitive dnaA mutant of Staphylococcus
RT   aureus.";
RL   FEMS Microbiol. Lett. 254:19-26(2006).
RN   [2] {ECO:0000313|Proteomes:UP000061420}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMUS2134 {ECO:0000313|Proteomes:UP000061420};
RA   Yamaguchi T., Suzuki S., Okumura S., Miura Y., Tsukimori A., Nakamura I.,
RA   Ito N., Shiina T., Matsumoto T.;
RT   "Evolution of mutations in Methicillin-Resistant Staphylococcus aureus ST72
RT   clinical isolates with reduced susceptibility to vancomycin and daptomycin
RT   by complete genome sequence analysis.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:BAR10237.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TMUS2134 {ECO:0000313|EMBL:BAR10237.1};
RA   Yamaguchi T., Suzuki S., Okamura S., Miura Y., Tsukimori A., Nakamura I.,
RA   Ito N., Masuya A., Shiina T., Matsumoto T.;
RT   "Evolution and Single-Nucleotide Polymorphisms in Methicillin-Resistant
RT   Staphylococcus aureus Strains with Reduced Susceptibility to Vancomycin and
RT   Daptomycin, Based on Determination of the Complete Genome.";
RL   Antimicrob. Agents Chemother. 59:3585-3587(2015).
RN   [4] {ECO:0000313|EMBL:KMR37007.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CA15 {ECO:0000313|EMBL:KMR37007.1}, and M121
RC   {ECO:0000313|EMBL:KMR57610.1};
RX   PubMed=26048971; DOI=10.1093/infdis/jiv320;
RA   Planet P.J., Diaz L., Kolokotronis S.O., Narechania A., Reyes J., Xing G.,
RA   Rincon S., Smith H., Panesso D., Ryan C., Smith D.P., Guzman M., Zurita J.,
RA   Sebra R., Deikus G., Nolan R.L., Tenover F.C., Weinstock G.M.,
RA   Robinson D.A., Arias C.A.;
RT   "Parallel Epidemics of Community-Associated Methicillin-Resistant
RT   Staphylococcus aureus USA300 Infection in North and South America.";
RL   J. Infect. Dis. 212:1874-1882(2015).
RN   [5] {ECO:0000313|EMBL:KIT95315.1, ECO:0000313|Proteomes:UP000032274}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SA-120 {ECO:0000313|EMBL:KIT95315.1,
RC   ECO:0000313|Proteomes:UP000032274};
RA   Crovadore J., Chablais R., Tonacini J., Schnyder B., Lefort F.;
RT   "Characterization of Swiss Staphylococcus aureus strains involved in food
RT   poisoning.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:KXA37244.1, ECO:0000313|Proteomes:UP000070177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PSS7673 {ECO:0000313|EMBL:KXA37244.1,
RC   ECO:0000313|Proteomes:UP000070177};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000265645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M1K003 {ECO:0000313|Proteomes:UP000265645};
RA   Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y., Kusuya Y.,
RA   Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N., Yamaide F.,
RA   Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G., Shimojo N.;
RT   "Protection against atopic dermatitis through acquisition of Staphylococcus
RT   quorum-sensing agr mutations in the skin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:SUK18367.1, ECO:0000313|Proteomes:UP000254224}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC7972 {ECO:0000313|EMBL:SUK18367.1,
RC   ECO:0000313|Proteomes:UP000254224};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:GBV20456.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M1K003 {ECO:0000313|EMBL:GBV20456.1};
RA   Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y., Kusuya Y.,
RA   Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N., Yamaide F.,
RA   Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G., Shimojo N.;
RT   "Protection against atopic dermatitis through acquisition of Staphylococcus
RT   quorum-sensing agr mutations in the skin.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:AXP69914.1, ECO:0000313|Proteomes:UP000259766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=64 {ECO:0000313|EMBL:AXP69914.1,
RC   ECO:0000313|Proteomes:UP000259766};
RA   Chako K., Divya B., Pak T., Sause W., Kumar K., Sebra R., Deikus G.,
RA   Attie O., Rose H., Lewis M., Li Y., Bashir A., Kasarskis A., Schadt E.,
RA   Richardson A.R., Torres V., Shopsin B.;
RT   "Colonizing and infecting subclones diverge during Staphylococcus aureus
RT   infection.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AXP69914.1, ECO:0000313|Proteomes:UP000259766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=64 {ECO:0000313|EMBL:AXP69914.1,
RC   ECO:0000313|Proteomes:UP000259766};
RA   Chako K.I., Sullivan M.J., van Bakel H.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|Proteomes:UP000509140, ECO:0000313|Proteomes:UP000510613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=07-059 {ECO:0000313|EMBL:QLH96774.1,
RC   ECO:0000313|Proteomes:UP000510613}, and 950122
RC   {ECO:0000313|EMBL:QLH99421.1, ECO:0000313|Proteomes:UP000509140};
RA   Cortes M.F., Botelho A.M.N., Bandeira P.T., Mouton W., Badiou C., Bess M.,
RA   Lima N.C.B., Soares A.E.R., Souza R.C., Almeida L.G.P., Vasconcelos A.T.R.,
RA   Nicolas M.F., Vandenesch F., Laurent F., Planet P., Figueiredo A.M.S.;
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|Proteomes:UP000430661, ECO:0000313|Proteomes:UP000442194}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S_1081.LBCF.DN {ECO:0000313|EMBL:MVM11424.1,
RC   ECO:0000313|Proteomes:UP000478867}, S_2062.LAUP.DI
RC   {ECO:0000313|EMBL:MVK35447.1, ECO:0000313|Proteomes:UP000471199},
RC   S_2078.LLFX.AN {ECO:0000313|EMBL:MVK03616.1,
RC   ECO:0000313|Proteomes:UP000430661}, and S_3122.LTHB.DN
RC   {ECO:0000313|EMBL:MVH47371.1, ECO:0000313|Proteomes:UP000442194};
RA   Stine O.C.;
RT   "Implementation of targeted gown and glove precautions to prevent
RT   Staphylococcus aureus acquisition in community-based nursing homes.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:NDQ60471.1, ECO:0000313|Proteomes:UP000462022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=67-013 {ECO:0000313|EMBL:NDQ60471.1,
RC   ECO:0000313|Proteomes:UP000462022};
RA   Little S.V., Hillhouse A.E., Cohen N.D., Lawhon S.D., Bryan L.K.;
RT   "Analysis of Virulence and Antimicrobial Resistance Gene Carriage in
RT   Staphylococcus aureus Infections in Equids Using Whole Genome Sequencing.";
RL   Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|Proteomes:UP000473113, ECO:0000313|Proteomes:UP000478593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UA786 {ECO:0000313|EMBL:NGW87020.1,
RC   ECO:0000313|Proteomes:UP000478593}, and UG255
RC   {ECO:0000313|EMBL:NGW67785.1, ECO:0000313|Proteomes:UP000473113};
RA   Castro-Cardozo B., Berrio M., Vargas M.L., Carvajal L.P., Millan L.V.,
RA   Rios R., Hernandez A., Rincon S.L., Cubides P., Forero E., Dinh A.,
RA   Seas C., Munita J.M., Arias C.A., Reyes J., Diaz L.;
RT   "Detection of Heterogeneous Vancomycin Intermediate Resistance in
RT   Methicillin Resistant Staphylococcus aureus Isolates from Latin-America.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:QID97902.1, ECO:0000313|Proteomes:UP000501532}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SA1428 {ECO:0000313|EMBL:QID97902.1,
RC   ECO:0000313|Proteomes:UP000501532};
RA   Lippolis J.;
RT   "DNA sequencing of a Staphylococcus aureus strain isolated from an
RT   intramammary infection in a dairy cow.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:CAC8226357.1, ECO:0000313|Proteomes:UP000507402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MOS114 {ECO:0000313|EMBL:CAC8226357.1,
RC   ECO:0000313|Proteomes:UP000507402};
RG   Pathogen Informatics;
RL   Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC       ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227}.
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DR   EMBL; CP031670; AXP69914.1; -; Genomic_DNA.
DR   EMBL; AB201418; BAD89355.1; -; Genomic_DNA.
DR   EMBL; AP014653; BAR10237.1; -; Genomic_DNA.
DR   EMBL; CAIIGN010000003; CAC8226357.1; -; Genomic_DNA.
DR   EMBL; BDVT01000006; GBV20456.1; -; Genomic_DNA.
DR   EMBL; JXIG01000630; KIT95315.1; -; Genomic_DNA.
DR   EMBL; LALJ01000007; KMR37007.1; -; Genomic_DNA.
DR   EMBL; LALQ01000017; KMR57610.1; -; Genomic_DNA.
DR   EMBL; LRQH01000088; KXA37244.1; -; Genomic_DNA.
DR   EMBL; WPRT01000037; MVH47371.1; -; Genomic_DNA.
DR   EMBL; WPUV01000038; MVK03616.1; -; Genomic_DNA.
DR   EMBL; WPTS01000027; MVK35447.1; -; Genomic_DNA.
DR   EMBL; WPXC01000030; MVM11424.1; -; Genomic_DNA.
DR   EMBL; JAAFKS010000013; NDQ60471.1; -; Genomic_DNA.
DR   EMBL; JAALTR010000230; NGW67785.1; -; Genomic_DNA.
DR   EMBL; JAALUV010000015; NGW87020.1; -; Genomic_DNA.
DR   EMBL; CP048431; QID97902.1; -; Genomic_DNA.
DR   EMBL; CP045439; QLH96774.1; -; Genomic_DNA.
DR   EMBL; CP045441; QLH99421.1; -; Genomic_DNA.
DR   EMBL; UHAI01000002; SUK18367.1; -; Genomic_DNA.
DR   RefSeq; WP_001290433.1; NZ_WYDB01000001.1.
DR   KEGG; sams:NI36_00005; -.
DR   KEGG; saud:CH52_05445; -.
DR   PATRIC; fig|1280.10341.peg.1; -.
DR   OMA; DFIHFYQ; -.
DR   Proteomes; UP000032274; Unassembled WGS sequence.
DR   Proteomes; UP000061420; Chromosome.
DR   Proteomes; UP000070177; Unassembled WGS sequence.
DR   Proteomes; UP000254224; Unassembled WGS sequence.
DR   Proteomes; UP000259766; Chromosome.
DR   Proteomes; UP000265645; Unassembled WGS sequence.
DR   Proteomes; UP000430661; Unassembled WGS sequence.
DR   Proteomes; UP000442194; Unassembled WGS sequence.
DR   Proteomes; UP000462022; Unassembled WGS sequence.
DR   Proteomes; UP000471199; Unassembled WGS sequence.
DR   Proteomes; UP000473113; Unassembled WGS sequence.
DR   Proteomes; UP000478593; Unassembled WGS sequence.
DR   Proteomes; UP000478867; Unassembled WGS sequence.
DR   Proteomes; UP000501532; Chromosome.
DR   Proteomes; UP000507402; Unassembled WGS sequence.
DR   Proteomes; UP000509140; Chromosome.
DR   Proteomes; UP000510613; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   NCBIfam; TIGR00362; DnaA; 1.
DR   PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48295; TrpR-like; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00377};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00377};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_00377};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00377};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00377}.
FT   DOMAIN          148..276
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          360..429
FT                   /note="Chromosomal replication initiator DnaA C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00760"
FT   BINDING         156..163
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   453 AA;  51966 MW;  FD182A5E25F9ABD9 CRC64;
     MSEKEIWEKV LEIAQEKLSA VSYSTFLKDT ELYTIKDGEA IVLSSIPFNA NWLNQQYAEI
     IQAILFDVVG YEVKPHFITT EELANYSNNE TATPKETTKP STETTEDNHV LGREQFNAHN
     TFDTFVIGPG NRFPHAASLA VAEAPAKAYN PLFIYGGVGL GKTHLMHAIG HHVLDNNPDA
     KVIYTSSEKF TNEFIKSIRD NEGEAFRERY RNIDVLLIDD IQFIQNKVQT QEEFFYTFNE
     LHQNNKQIVI SSDRPPKEIA QLEDRLRSRF EWGLIVDITP PDYETRMAIL QKKIEEEKLD
     IPPEALNYIA NQIQSNIREL EGALTRLLAY SQLLGKPITT ELTAEALKDI IQAPKSKKIT
     IQDIQKIVGQ YYNVRIEDFS AKKRTKSIAY PRQIAMYLSR ELTDFSLPKI GEEFGGRDHT
     TVIHAHEKIS KDLKEDPIFK QEVENLEKEI RNV
//

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