ID Q5HZP6_XENLA Unreviewed; 388 AA.
AC Q5HZP6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Coagulation factor 2 (Thrombin) receptor-like 1 S homeolog precursor {ECO:0000313|RefSeq:NP_001088959.1};
DE SubName: Full=LOC496339 protein {ECO:0000313|EMBL:AAH88935.1};
GN Name=f2rl1.S {ECO:0000313|RefSeq:NP_001088959.1,
GN ECO:0000313|Xenbase:XB-GENE-17343163};
GN Synonyms=LOC496339 {ECO:0000313|EMBL:AAH88935.1}, par2
GN {ECO:0000313|RefSeq:NP_001088959.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH88935.1};
RN [1] {ECO:0000313|RefSeq:NP_001088959.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH88935.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg {ECO:0000313|EMBL:AAH88935.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001088959.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BC088935; AAH88935.1; -; mRNA.
DR RefSeq; NP_001088959.1; NM_001095490.1.
DR DNASU; 496339; -.
DR GeneID; 496339; -.
DR KEGG; xla:496339; -.
DR AGR; Xenbase:XB-GENE-17343163; -.
DR CTD; 496339; -.
DR Xenbase; XB-GENE-17343163; f2rl1.S.
DR OrthoDB; 4075920at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 496339; Expressed in zone of skin and 18 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015057; F:thrombin-activated receptor activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002281; Pro_rcpt_2.
DR InterPro; IPR003912; Protea_act_rcpt.
DR PANTHER; PTHR24232; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24232:SF21; PROTEINASE-ACTIVATED RECEPTOR 2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01428; PROTEASEAR.
DR PRINTS; PR01152; PROTEASEAR2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR603912-52};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:NP_001088959.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001088959.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..388
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001088959.1"
FT /id="PRO_5033207075"
FT TRANSMEM 66..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..334
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DISULFID 138..216
FT /evidence="ECO:0000256|PIRSR:PIRSR603912-52"
SQ SEQUENCE 388 AA; 44184 MW; 773BA973D4A56793 CRC64;
MGVWRLLILG AVLFFPIIAG QNLSTPIKKG RVFIAHKVEI GNGTGKYIYT VAPFVSQVLS
DPLTTAFLPA VYIIVFIIGL PSNAIALWVF FFRTKKKHPA MIYMANLALA DLMFVIWLPF
KIEYHLNGNN WTYGEPLCKV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP MSHTRKNTKR
ALIVSIAIWV VIMLGTIPLY LINQTLYLSD LGITTCHDVL PLDSATFDLF NYFLALAIGV
FFLPAILTAV VYTLMIKTLT ASITDESIGK KRKRAIRLII IVLVMYLVCF LPSNLLLVIH
YGSLKNNYSD SVYTFYITAL CLSSLNSFID PFVYYFVSKD FRDHVKNMFL CRSVRTVERM
RISFSSMKYS RKTNSYTTKS TDTKTSSC
//
