ID Q5JHM2_THEKO Unreviewed; 262 AA.
AC Q5JHM2;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein {ECO:0000259|Pfam:PF02900};
GN OrderedLocusNames=TK2203 {ECO:0000313|EMBL:BAD86392.1};
OS Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS (Pyrococcus kodakaraensis (strain KOD1)).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=69014 {ECO:0000313|EMBL:BAD86392.1, ECO:0000313|Proteomes:UP000000536};
RN [1] {ECO:0000313|EMBL:BAD86392.1, ECO:0000313|Proteomes:UP000000536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-918 / JCM 12380 / KOD1
RC {ECO:0000313|Proteomes:UP000000536};
RX PubMed=15710748; DOI=10.1101/gr.3003105;
RA Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL Genome Res. 15:352-363(2005).
RN [2] {ECO:0007829|PDB:5HEE}
RP X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) IN COMPLEX WITH ZINC.
RX PubMed=27303894; DOI=10.1107/S2053230X16006920;
RA Nishitani Y., Simons J.R., Kanai T., Atomi H., Miki K.;
RT "Crystal structure of the TK2203 protein from Thermococcus kodakarensis, a
RT putative extradiol dioxygenase.";
RL Acta Crystallogr. F Struct. Biol. Commun. 72:427-433(2016).
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DR EMBL; AP006878; BAD86392.1; -; Genomic_DNA.
DR RefSeq; WP_011251153.1; NC_006624.1.
DR PDB; 5HEE; X-ray; 1.41 A; A/B=1-262.
DR PDBsum; 5HEE; -.
DR AlphaFoldDB; Q5JHM2; -.
DR SMR; Q5JHM2; -.
DR STRING; 69014.TK2203; -.
DR EnsemblBacteria; BAD86392; BAD86392; TK2203.
DR GeneID; 78448743; -.
DR KEGG; tko:TK2203; -.
DR PATRIC; fig|69014.16.peg.2158; -.
DR eggNOG; arCOG01729; Archaea.
DR HOGENOM; CLU_089900_0_0_2; -.
DR InParanoid; Q5JHM2; -.
DR OrthoDB; 55814at2157; -.
DR PhylomeDB; Q5JHM2; -.
DR Proteomes; UP000000536; Chromosome.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProt.
DR GO; GO:0008198; F:ferrous iron binding; IEA:InterPro.
DR GO; GO:0006725; P:cellular aromatic compound metabolic process; IEA:InterPro.
DR CDD; cd07952; ED_3B_like; 1.
DR Gene3D; 3.40.830.10; LigB-like; 1.
DR InterPro; IPR004183; Xdiol_dOase_suB.
DR Pfam; PF02900; LigB; 1.
DR SUPFAM; SSF53213; LigB-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5HEE}; Metal-binding {ECO:0007829|PDB:5HEE};
KW Reference proteome {ECO:0000313|Proteomes:UP000000536};
KW Zinc {ECO:0007829|PDB:5HEE}.
FT DOMAIN 8..254
FT /note="Extradiol ring-cleavage dioxygenase class III enzyme
FT subunit B"
FT /evidence="ECO:0000259|Pfam:PF02900"
FT BINDING 10
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:5HEE"
FT BINDING 48
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:5HEE"
FT BINDING 55
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:5HEE"
FT BINDING 172
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:5HEE"
FT BINDING 198
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0007829|PDB:5HEE"
FT BINDING 202
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0007829|PDB:5HEE"
FT BINDING 222
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:5HEE"
SQ SEQUENCE 262 AA; 29443 MW; 4825BBFA45A5F27D CRC64;
MLFGIGLMPH GNPALSPEDK ETEKLAGVLK DIGKAFSDAD SYVLISPHNV RISDHLGVIM
AQHLISWLGF EGVELPGEWE TDRGLAEEVY NAWKGAEIPT VDLHFASRSG RYSRWPLTWG
ELIPLQFLEK KPLVLLTPAR RLSRETLIKA GEVLGEVLEG SEKKIALIVS ADHGHAHDEN
GPYGYRKESE EYDRLIMELI NESRLEELPE IPDELIEKAL PDSYWQMLIM LGAMHRVPVK
LVESAYACPT YFGMAGALWV RE
//
