ID Q5K7G6_CRYNJ Unreviewed; 480 AA.
AC Q5K7G6; Q55HY2;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=FAD-dependent oxidoreductase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00039785};
GN OrderedLocusNames=CNM02510 {ECO:0000313|EMBL:AAW46735.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46735.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46735.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017353; AAW46735.2; -; Genomic_DNA.
DR RefSeq; XP_568252.1; XM_568252.1.
DR AlphaFoldDB; Q5K7G6; -.
DR STRING; 214684.Q5K7G6; -.
DR PaxDb; 214684-Q5K7G6; -.
DR EnsemblFungi; AAW46735; AAW46735; CNM02510.
DR VEuPathDB; FungiDB:CNM02510; -.
DR HOGENOM; CLU_022730_0_1_1; -.
DR InParanoid; Q5K7G6; -.
DR OrthoDB; 2600928at2759; -.
DR Proteomes; UP000002149; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR13847:SF287; FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 67..452
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
SQ SEQUENCE 480 AA; 52511 MW; 079A06490AE83B43 CRC64;
MTITLDKRTI PAVGSEATTQ GEVQNGRQMT ALPLESGFCL SLWLQTVRNN PLLNHRTTDE
LPREAEVVII GSGISGSLCA LSLLQGPDPP KSVVILEARE LCSGATGRNA GHCKPDQWRG
FTKYQKRHGT EQALKILKNE QDTWESMAAY VKKHNVQCDF WTGKTLDVCM TDEVAEMAAK
TFSYYMEAGG DVSKIEVTTD SQRAEEISRL KGARAVYAWD ASTLHPWKLV AHIAQQALDL
GLNLQTWTPV TSISGSAHQW TVHTDRGSIT ASKVVHTTNA YAGFLLPEMR VAIHPTPHMC
DKVIPPTSHS GTKSLQNSYA VIYPTGLYSI NPRLNADGAV LFGGSAPNQQ RLLDYVAEDP
KNRQTNDSLT NFEPVTEAVR KLGREGLEWD LAKGAKGTGA RYDYSWSGII GRSADDVPFI
GAVPDKPGQW MSCGHNGHGM ARIFTAAPAL AKMVQGATYA ETGLPECFEI TQERLEKLRT
//
