ID Q5K8W8_CRYNJ Unreviewed; 495 AA.
AC Q5K8W8; Q55LV2;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Nucleus protein, putative {ECO:0000313|EMBL:AAW46458.1};
GN OrderedLocusNames=CNL04230 {ECO:0000313|EMBL:AAW46458.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46458.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46458.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017352; AAW46458.1; -; Genomic_DNA.
DR RefSeq; XP_567975.1; XM_567975.1.
DR AlphaFoldDB; Q5K8W8; -.
DR STRING; 214684.Q5K8W8; -.
DR PaxDb; 214684-Q5K8W8; -.
DR EnsemblFungi; AAW46458; AAW46458; CNL04230.
DR GeneID; 3254731; -.
DR KEGG; cne:CNL04230; -.
DR VEuPathDB; FungiDB:CNL04230; -.
DR eggNOG; KOG1338; Eukaryota.
DR HOGENOM; CLU_017135_0_0_1; -.
DR InParanoid; Q5K8W8; -.
DR OMA; RVDWWLE; -.
DR OrthoDB; 51002at2759; -.
DR Proteomes; UP000002149; Chromosome 12.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IBA:GO_Central.
DR Gene3D; 3.90.1420.10; Rubisco LSMT, substrate-binding domain; 1.
DR Gene3D; 3.90.1410.10; set domain protein methyltransferase, domain 1; 1.
DR InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR13271:SF34; N-LYSINE METHYLTRANSFERASE SETD6; 1.
DR PANTHER; PTHR13271; UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE; 1.
DR Pfam; PF09273; Rubis-subs-bind; 1.
DR SUPFAM; SSF81822; RuBisCo LSMT C-terminal, substrate-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 31..276
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 198..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 56001 MW; C26FA50B8CAE0165 CRC64;
MTSQALIQAE AFESQKFLTW FKESGGWYNE ELVDIVSVPG MGYGAVAVKD IEEGTPLFHV
PDDLILSAYT SDLKDHLDAS EWDQLNKGWA QLILVMMWET IKGSKSRWAG YLANMPVLFE
TPMFWTERQR EQLSGTDIAD RIGREDAEAE YTSVLAPFIK AHPDLFPVDS PHITMDAFHI
QGSRILSRSF TVPLHRFGRS HSQSRSDGNS EKESDDEDEE EMVVMIPFAD MLNAAWGKDN
AHLYVDEDTI EGFDEGVVMK STQLVKQSEQ IYNTYDSPPN SELLRKYGHV DVLPLPSDML
DLLNETELGS WPYGNPGDEV LLQGDLIVGC VTTKLGGAHM KATLQDRIDW WLEEGQEDIF
PLNFSHDIDD GLISFIRLLL HDSDWDRAHK KGRMPRAIID ETVADVLHEI INQRLAQYKQ
NIEHDLKVVR SSYHGADDKP VTSLGRNESA AVVRLGEKRI LYLARRKIAQ ATAGQKSSQK
RKNNSTLMGK GKRIH
//
