ID Q5KAQ0_CRYNJ Unreviewed; 863 AA.
AC Q5KAQ0; Q55KS5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Rab family GTP-binding protein, putative {ECO:0000313|EMBL:AAW45955.2};
GN OrderedLocusNames=CNJ00920 {ECO:0000313|EMBL:AAW45955.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW45955.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW45955.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017350; AAW45955.2; -; Genomic_DNA.
DR RefSeq; XP_567472.1; XM_567472.1.
DR AlphaFoldDB; Q5KAQ0; -.
DR STRING; 214684.Q5KAQ0; -.
DR PaxDb; 214684-Q5KAQ0; -.
DR EnsemblFungi; AAW45955; AAW45955; CNJ00920.
DR VEuPathDB; FungiDB:CNJ00920; -.
DR eggNOG; KOG0092; Eukaryota.
DR HOGENOM; CLU_333995_0_0_1; -.
DR InParanoid; Q5KAQ0; -.
DR OrthoDB; 1476517at2759; -.
DR Proteomes; UP000002149; Chromosome 10.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR CDD; cd00154; Rab; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47978; -; 1.
DR PANTHER; PTHR47978:SF52; INTRAFLAGELLAR TRANSPORT PROTEIN 27 HOMOLOG; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00176; RAN; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT REGION 87..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..129
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..241
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 92464 MW; 1EBC6DACE3E08C23 CRC64;
MSVLATPLPH RPFSDTELFT SSSGSVPAHA ELPPVPPHIA LPIPLPPQGT SFSTFQQRHT
SSYPMPQQQT FSALGPAQPD VVPTNAIMPH AETSPSAPQG SAVGLADLTP DIHPQTPLPP
TPEPSPPRRK VLGPTMMIKL APPADDHSYH RYDVLGTEAE PSSVHSGESS GSTSTTPRRL
PTLSIDIESF DSSPSHRTPS PKLGTSSGTP SQARVKSSSS TDPKPPRPKS MGPPPRPRRS
QTAYPHGPVS VRMAESRSAD SRERKLRATS VLRASSYSQV RSGSPGPSRA FSDAGSGSVT
PRAFSASDLA LPDLGGPDGL EAKVVLLGSQ GVGKTSLILR YTTRTFSVTP APATIGSSLH
TRKLVHSGVR VKLQIWDTAG QERFRSMAPI YYRGAHVCVL VYDISDKQSF EDVRSWLEEL
GRSVPKETVI FVAGAKIDLN DRREVEFDFA KEMIRSWISP PSPPPPVLTP MTSPPQRSLF
RSSTSTSRID SPSPTPTISR APSTRIHSYS SHITEPTLRS APISSSSRHS ADSPRPLASV
PFPSPKDIPV SPEKSKAKEI ANEKRSRRHS AKPFPVKVTN SASTSLATSP SRLEFPTLQS
PTGPTSATFT EPVGPLLASP TSSPGHRSSG GRFSISGISE VLGLNRTVSM SGAISSLHQL
TEAPSPPPLQ TSSPGSSSFN PPQLPSSPRT RVESSPLFPS YGSDRNARRK SDEWSRGGWK
MGEGPGVAEA LGEFGAGVKR RESEELLGGT NRSLPVLGNP SYKVNQVRSR AGSLGRDPRL
IGELEEVEDE WGVQVENVRL GECSALTGEG VEKLFKAISS ILVERKDKIE RERVLRHKDS
VILVDPSTNP RGLDKEKKSG CCV
//
