ID Q5KBU2_CRYNJ Unreviewed; 519 AA.
AC Q5KBU2; Q55NF6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Choline kinase, putative {ECO:0000313|EMBL:AAW45675.1};
GN OrderedLocusNames=CNI01400 {ECO:0000313|EMBL:AAW45675.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW45675.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW45675.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
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DR EMBL; AE017349; AAW45675.1; -; Genomic_DNA.
DR RefSeq; XP_572982.1; XM_572982.1.
DR AlphaFoldDB; Q5KBU2; -.
DR STRING; 214684.Q5KBU2; -.
DR PaxDb; 214684-Q5KBU2; -.
DR EnsemblFungi; AAW45675; AAW45675; CNI01400.
DR GeneID; 3259492; -.
DR KEGG; cne:CNI01400; -.
DR VEuPathDB; FungiDB:CNI01400; -.
DR eggNOG; KOG2686; Eukaryota.
DR HOGENOM; CLU_012712_5_1_1; -.
DR InParanoid; Q5KBU2; -.
DR OMA; IETSIDY; -.
DR OrthoDB; 144299at2759; -.
DR Proteomes; UP000002149; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004103; F:choline kinase activity; IBA:GO_Central.
DR GO; GO:0004305; F:ethanolamine kinase activity; IBA:GO_Central.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IBA:GO_Central.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05157; ETNK_euk; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR PANTHER; PTHR22603:SF93; RE24176P; 1.
DR Pfam; PF01633; Choline_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:AAW45675.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transferase {ECO:0000313|EMBL:AAW45675.1}.
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 58268 MW; F777D06C7BEA9AEF CRC64;
MVVTPTRPPV EPSGPPLSPL ALASTAPRNS SDSYFAAQAG SRPLPRHRRT SGSSFSKLSE
FSLDPPLLDK TDQYAASPDQ IDENGVTGVR HVALSVDASE WRQPVFKQKV LAILRRLHVP
RWSSTLLTPT NIHLQKVSGA LTNAVFFVSF NPAPNPTSPS ESPLLTPTIP PSDPSHPPPL
TPDQYPHTLL FRVYGPSSEA LISRSEELRI LHVLSTQYGI GPRVFGTFTN GRVEEFFPSR
ALTAQELRDP SISRGIARRM RELHSVDLRR LGYEQGRATE PALWICLKEW SEAAEDVITS
LTALGGTLEA WVERFSLHRI REEVTIYRNF VESQSGKGSG VVFAHNDTQY GNLLRLDVEL
PPNTPEHCRY IVIDFEYASP NPRGYDIANH FHEWRANYHH PTHSHSLIPH FPYPTPIQRE
DFYRSYLSVE VDGRNGEEVV GKRKDVPADK VAALEREVRI WSPGCSINWA LWGLVQAEEQ
VCALATKKEG YVPEFDYLSY AAERLEMFRD EAKKLGVPL
//
