ID Q5KF12_CRYNJ Unreviewed; 982 AA.
AC Q5KF12;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=General RNA polymerase II transcription factor, putative {ECO:0000313|EMBL:AAW44114.2};
GN OrderedLocusNames=CNF03480 {ECO:0000313|EMBL:AAW44114.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44114.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44114.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017346; AAW44114.2; -; Genomic_DNA.
DR RefSeq; XP_571421.1; XM_571421.1.
DR AlphaFoldDB; Q5KF12; -.
DR STRING; 214684.Q5KF12; -.
DR PaxDb; 214684-Q5KF12; -.
DR EnsemblFungi; AAW44114; AAW44114; CNF03480.
DR VEuPathDB; FungiDB:CNF03480; -.
DR eggNOG; KOG0192; Eukaryota.
DR HOGENOM; CLU_008519_0_0_1; -.
DR InParanoid; Q5KF12; -.
DR OrthoDB; 52293at2759; -.
DR Proteomes; UP000002149; Chromosome 6.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd13999; STKc_MAP3K-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR23257:SF703; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 715..978
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..300
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..365
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..381
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..557
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..641
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 982 AA; 110295 MW; A8007D0501D77C76 CRC64;
MDRLQRTRSQ HFVSSPRKTA SPLIARHTLY PRHPPKKRRL GVTTFVASHN EAGQNYSNEL
EDDLEKAIMK TGESSSAPAR RTSRSRSQSR PVRRKSNDKV WADSLPNGQD GEDAASPKKR
KRSRAGSLST EDSWVETSGD EWEPDFIAES DRNMIHYAPS TALHRLRKAE LVRLWRVAGM
WDSEDIPDDM NEDETIGDMG KKELVDGLIS ARKHQTGRLI SPLPSSPNRL IRRQSTLSPI
PATPPPSSPL AESSSPDVTP KPRPRTRSRV RLETPVVRRQ PRPSRPTRTL TKRHTKSEAR
SRRVRAQLTK KVNGKSENGD EIELTESSDS DDDVNGIEST PIVKRLRPRG VGERKSFMKE
PSTDITDFED DAEEADAEAT EVEEEPQPKE RKLRRKSISQ ASLSKYGGDI DMAPTSEQRS
SKNLPTRGAK KKAIQRMQGG ESGTEDEDME VDEERDIGMK EGTPTPQPAI PPRRGRASRS
STPKLDEDSA MVGSPTPSVA TETEASTPRP VHTTRSGKTF GAIQNRRRQL LQEARNDPDM
DEEDESDEED GEPELDIDLS EATVASLIRL LRDELVQMCE TRGIEVGGTK PQLAKALLEW
RDEQKGSYPS SASTARPSPP RTAMPRRKSK SKSKTKSKFK SNKHVPAIGT AAHAPGKPTP
VLLRSHIHAN DPETPPLSKG EEGDVEEEKK GTEAELNLDL QELGLEDSVI KPSQLIKLEK
IGSGGFKDVY VGKFRGRKVA ISEFRSHLSE MDIRELKLLA EFSHPNIVRF RGICIPEDST
HVPCMLVSEL CENGDLFDYI RNVPCPTLKR LLSLMLDIAR GLEYLHTRKP SIIHRDCKSS
NILINRSGVA KVGDFGLARV KNSTRSMIRS LVGTVNWQAP ELWHPTPRYD YKVDVFSAGM
VYWEMMSGWI GEKKYPWEGH NEHYIYDAVG TKHRRPPVTG MRKHWGSEPV NLMERMWHQD
PAERPTMTDV VHDLESILAE LK
//
