ID Q5KHL2_CRYNJ Unreviewed; 617 AA.
AC Q5KHL2; Q55US7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 95.
DE RecName: Full=Vps72/YL1 C-terminal domain-containing protein {ECO:0000259|SMART:SM00993};
GN OrderedLocusNames=CND06080 {ECO:0000313|EMBL:AAW42787.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42787.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42787.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the VPS72/YL1 family.
CC {ECO:0000256|ARBA:ARBA00006832}.
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DR EMBL; AE017344; AAW42787.2; -; Genomic_DNA.
DR RefSeq; XP_570094.1; XM_570094.1.
DR AlphaFoldDB; Q5KHL2; -.
DR STRING; 214684.Q5KHL2; -.
DR PaxDb; 214684-Q5KHL2; -.
DR EnsemblFungi; AAW42787; AAW42787; CND06080.
DR VEuPathDB; FungiDB:CND06080; -.
DR eggNOG; KOG2897; Eukaryota.
DR HOGENOM; CLU_029477_0_0_1; -.
DR InParanoid; Q5KHL2; -.
DR OrthoDB; 2056942at2759; -.
DR Proteomes; UP000002149; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0140849; F:ATP-dependent H2AZ histone chaperone activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR008895; Vps72/YL1.
DR InterPro; IPR013272; Vps72/YL1_C.
DR InterPro; IPR046757; YL1_N.
DR PANTHER; PTHR13275:SF4; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG; 1.
DR PANTHER; PTHR13275; YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1; 1.
DR Pfam; PF05764; YL1; 1.
DR Pfam; PF08265; YL1_C; 1.
DR SMART; SM00993; YL1_C; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 487..516
FT /note="Vps72/YL1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00993"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..438
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 617 AA; 68855 MW; 44AB38B80DABE35D CRC64;
MPLTTEYETI TQGRAKRSTA GNRMRELLEK AHQEDDDELF KEVEDDEEFV APPEQKDIFL
DEFADTDSAP SDEDEEAQLL RAERRAKRDA QSKGKGKLRI NPLSAPKYGY GYGAKAKEQG
FKLKESDLAL LGEDVDVASM APSTLVLELR RRKREAKRVH RSEARRSNLR ASTLGTAAAA
ANTDPDAQGK AEAEEDDGKN RGRRGRVAQH VATTRTLRKP LTQSQLIEAA LEEEERNKEA
LRDWLKKEEE KRELRRVGRK VVKGPRWTWV SRTVGRLVEE VPEPAKAEEL SHEQDKSQGA
EKSQGECSKA PQSEGSKINS ASPPSITQSA DTTALLNPAP GTHQPEPEPE PEPEPEPEPQ
PEPEPQPEPE PQPEPEPQPE PEPQPEPQPQ PEPQPQPEPQ PQPQPQPQPQ PQPQPQPQPQ
PQPQPQPQPQ PQPQPEPNAP YTRNYIILSQ IPGGLPAELQ VVLGSHVEWD KLKIIPSRNR
PINRQIPLCP FTNLPAKYRH PTTLIPFATK EGYQAIEALL RNRYEWVEPG GWWGVGEGDV
VADGMGGVDG LEAGPGIGGW YAGERVDRLS RSEPREGQEQ EHGHGQETTP ADGQMEEKIG
IKRARESQTA TKSKRRR
//
