ID Q5KK89_CRYNJ Unreviewed; 725 AA.
AC Q5KK89;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=Adrenoleukodystrophy protein, putative {ECO:0000313|EMBL:AAW42317.1};
GN OrderedLocusNames=CNC03860 {ECO:0000313|EMBL:AAW42317.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42317.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42317.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCD family.
CC Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
CC {ECO:0000256|ARBA:ARBA00008575}.
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DR EMBL; AE017343; AAW42317.1; -; Genomic_DNA.
DR RefSeq; XP_569624.1; XM_569624.1.
DR AlphaFoldDB; Q5KK89; -.
DR STRING; 214684.Q5KK89; -.
DR PaxDb; 214684-Q5KK89; -.
DR EnsemblFungi; AAW42317; AAW42317; CNC03860.
DR GeneID; 3256288; -.
DR KEGG; cne:CNC03860; -.
DR VEuPathDB; FungiDB:CNC03860; -.
DR eggNOG; KOG0064; Eukaryota.
DR HOGENOM; CLU_007587_1_1_1; -.
DR InParanoid; Q5KK89; -.
DR OMA; DIQAGHF; -.
DR OrthoDB; 7698at2759; -.
DR Proteomes; UP000002149; Chromosome 3.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005324; F:long-chain fatty acid transporter activity; IBA:GO_Central.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR GO; GO:0015910; P:long-chain fatty acid import into peroxisome; IBA:GO_Central.
DR GO; GO:0007031; P:peroxisome organization; IBA:GO_Central.
DR GO; GO:0042760; P:very long-chain fatty acid catabolic process; IBA:GO_Central.
DR CDD; cd03223; ABCD_peroxisomal_ALDP; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11384; ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER; 1.
DR PANTHER; PTHR11384:SF69; PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1; 1.
DR Pfam; PF06472; ABC_membrane_2; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 470..705
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 57..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 81019 MW; B29301B6BF2F3C89 CRC64;
MPSSHIVPLT KDTLRSRFKF ILNSYLQHRP IFQRAFTAAF VIYCLISTYG SLTGRGAKGA
PGGKGNGKRD KGAKHGITGS IKDPLFHVRL KRLIRIVIPS LKSKEAAMLA LHSAFLVGRT
GLSLYVADLD GRIVSSLVTA NPHAFLMNIA RWLLVAIPAT YTNSMLEYLQ SELGLAYRTR
LTKYALTMYL DPPGVESGGD KDGEQLFYKL ANLDDRIKNA DQYLAEDIQQ LSSKLAEIYS
NIAKPVLDVI LYNYQLSRNV GAESLVLLTI LVQTSATLLR AITPPFGAYT AHEAKLEGEL
RFTHSRLLES AEEVALYHGE EFEKNVIERG YFALVKHINR ILKIRVGHGM AEEGVIKWLW
GSLGLCICAI PVFGGSALGM KEGDLGSRTE GFVTNRRLLL SSSDAFGRVM YSYKDMAELA
GYTSRVSELF ETMEHAKKGE YQKKLVSSVS TENNAKILQG RGKIIESDEI EFDQVPLISP
NGDVLVKSMS FHVKPGKHLL VIGPNGCGKS SLFRILGGLW PVYGGTVYKP PSNQFTYIPQ
RPYLCTGTLR DQIIYPHSHA DMLSHGKSDE DLSKILEVVE MAGIIEREGG WDAVREWRDT
LSGGDKQRIA MARLFYHKPK YAILDECTSA VTLEIEKTMY DHATSLGITL MTVSHRPSLW
KFHTMVLEYD GQGGYTFTHL DAEKRLALQE EKQELEHKLL SVPKLKDRLE ELKMIKEQRE
FTSGI
//
