ID Q5KNA9_CRYNJ Unreviewed; 580 AA.
AC Q5KNA9;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 102.
DE RecName: Full=aldehyde dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00024226};
DE EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
GN OrderedLocusNames=CNA07130 {ECO:0000313|EMBL:AAW41213.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW41213.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW41213.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; AE017341; AAW41213.2; -; Genomic_DNA.
DR RefSeq; XP_567032.1; XM_567032.1.
DR AlphaFoldDB; Q5KNA9; -.
DR STRING; 214684.Q5KNA9; -.
DR PaxDb; 214684-Q5KNA9; -.
DR EnsemblFungi; AAW41213; AAW41213; CNA07130.
DR VEuPathDB; FungiDB:CNA07130; -.
DR eggNOG; KOG2453; Eukaryota.
DR HOGENOM; CLU_005391_1_2_1; -.
DR InParanoid; Q5KNA9; -.
DR OrthoDB; 8449at2759; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0043878; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; IEA:UniProtKB-EC.
DR CDD; cd07130; ALDH_F7_AASADH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR044638; ALDH7A1-like.
DR PANTHER; PTHR43521; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43521:SF1; ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 88..557
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 322
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 580 AA; 61652 MW; 6C67341360E60315 CRC64;
MRSSSVLSLS WTAPRSHRRT VALLPIRQQR NTTIMRAMSN IIGGTESKVP SGTRPLSTRA
HAVLSALNIP ADNAAPIPGV FDGQWKGSGE EITSKCPATG EILARVKGAS VEETQAAIAK
SKEAYRIVRS MPAPKRGEVI RQIREALEAK VSELGDLVSL EMGKIKSEGK GEVQEFIDVC
DFATGLSRTM TGRVLPSERP EHVIYEIPNP LGVVGILSAF NFPVAVYGWN LTVALASGNS
TIWKPAPSTP LTAIAVARLI QPVLEKNGLP GATAALVCGG IDVGKIIVGS EDIPLVSFTG
SEKVGKEVGK AVNDRFGKTI LELGGNNAVI VDKDADLPLA LQSVLFAAVG TAGQRCTSTR
RLILHKSIAQ EFLSKLLPVY DAQAPSPHLM VGDPLQTSTL IGPLHNEAAV KKYEATLQAV
TSRGGEILTQ RSGRINGMNK EVEGGNWVWP TVVRPKKDDP CWKEEVFAPI LFVTEFETLE
EAIEINNSVP QGLSSALFTS DLRSLGKWLG PEGSDCGIVN VNVGTSGAEI GAGFGGNKST
GWGRESGGDA WKQYVRWSAA TVNYSSKVSL AQGVTFGIDA
//
