ID Q5KNB9_CRYNJ Unreviewed; 811 AA.
AC Q5KNB9; Q55Z03;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 127.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN OrderedLocusNames=CNA07030 {ECO:0000313|EMBL:AAW41201.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW41201.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW41201.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AE017341; AAW41201.2; -; Genomic_DNA.
DR RefSeq; XP_567020.1; XM_567020.1.
DR AlphaFoldDB; Q5KNB9; -.
DR STRING; 214684.Q5KNB9; -.
DR PaxDb; 214684-Q5KNB9; -.
DR EnsemblFungi; AAW41201; AAW41201; CNA07030.
DR VEuPathDB; FungiDB:CNA07030; -.
DR eggNOG; KOG0922; Eukaryota.
DR HOGENOM; CLU_001832_5_10_1; -.
DR InParanoid; Q5KNB9; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:AAW41201.2};
KW Helicase {ECO:0000313|EMBL:AAW41201.2};
KW Hydrolase {ECO:0000313|EMBL:AAW41201.2};
KW Nucleotide-binding {ECO:0000313|EMBL:AAW41201.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 107..337
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 352..538
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 89635 MW; 96983A4061BE6CC5 CRC64;
MTVAASTSSQ LPSSVKPQPR VSNFNDSSDE DEAESTPKAE KKKKKVNNLD VNGVYSPKSP
KKRKIGQANG DLGKGKKDGA EARRREAERL LVKRKELPFY QGRRMILEEI MANDTTIILG
ETGCGKSTQL PQLLRTHPVS VNHFSPSSSN RFRGPSIAIT QPRRLPAIAL ANRVSQEMGC
QIGGEVGYSV RFEDVTSRET RVRYLTEGVL MRELAGSDPK ICPPEKGANG TANGEDENDS
HMSEGQGLNL LLNYDVVIID EAHERTLNTD FLCGALKRVQ RIRKDIARRQ AEEEFQGKEK
IPGKKKVKEL KLVIMSATLD PTKFKTFFGT GRDALLVKGR MYEVATQHVL EPVDDFIEAA
ARQVMTIHCS PDSPGDVLVF MPGSEEIENC VELLKRVSKQ LAPGSPALQV LPLYAALPPT
AQSKIFIPTP DNTRRVIVAT NIAETSMTIP GVAFVVDSGF KKEKEYVFRN AGALEHLRKK
GISKASAWQR TGRAGRERAG HCYRLFTQDF FDKMPEFDAP EIQRCNLSSA VLQLIAMGQN
PFEFEYIDNP GRDSILAAFQ ELVGLSALSS PTTITPLGLQ MLRFPLDPPH ARILLAAFEY
GCANEIIDII SLVNAGGNVF IDRPNDREEA AQARQKFIHR EGDHLTMMNV FRAYTELKES
KSSSHSNSSS QSLVGWCKDN HVNSKTLAQA LKVREQLREL SERLGKDWKA SCGSEWGMVG
RSLLQGLFMN TAVIQADGSY RQTAGSLTVK IHPSSVLMSK KVPAILYDEL TITTAFYARN
VSAFEQHWLT EVPWFAKAGT SVAAPVGKGN L
//
