ID Q5LEE5_BACFN Unreviewed; 670 AA.
AC Q5LEE5; A0A380YY38;
DT 21-JUN-2005, integrated into UniProtKB/TrEMBL.
DT 21-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN Name=nahA {ECO:0000313|EMBL:CAH07506.1};
GN ORFNames=BF9343_1725 {ECO:0000313|EMBL:CAH07506.1};
OS Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS / NCTC 9343 / Onslow).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=272559 {ECO:0000313|EMBL:CAH07506.1, ECO:0000313|Proteomes:UP000006731};
RN [1] {ECO:0000313|EMBL:CAH07506.1, ECO:0000313|Proteomes:UP000006731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 /
RC Onslow {ECO:0000313|Proteomes:UP000006731};
RX PubMed=15746427; DOI=10.1126/science.1107008;
RA Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA Barrell B.G., Parkhill J.;
RT "Extensive DNA inversions in the B. fragilis genome control variable gene
RT expression.";
RL Science 307:1463-1465(2005).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
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DR EMBL; CR626927; CAH07506.1; -; Genomic_DNA.
DR RefSeq; WP_010992683.1; NZ_UFTH01000001.1.
DR CAZy; GH20; Glycoside Hydrolase Family 20.
DR PaxDb; 272559-BF9343_1725; -.
DR KEGG; bfs:BF9343_1725; -.
DR eggNOG; COG3525; Bacteria.
DR HOGENOM; CLU_013588_0_0_10; -.
DR BioCyc; BFRA272559:G1GHZ-1862-MONOMER; -.
DR Proteomes; UP000006731; Chromosome.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000006731}.
FT DOMAIN 26..143
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 146..249
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 285
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 670 AA; 77198 MW; 03CE3F23FEEB67A4 CRC64;
MRNKQIFLIS FIIYLCTISS VRAGEYHLLP EPQKFTPLGS SFVLGRTKLS TPVLRQEWEA
FVVDRGGVID DKARASIEVK LVPSLEEVPL NADEAYRLVV NNGKVTVEAV TEHGVYWAMQ
TLAQLQDVQK KKATFNGCSI VDWPAFRIRG FMQDVGRTYM SIEELKREIA VLSRFKINVF
HWHLTENQSW RLQSKIFPML NDSVNTTRMP GKYYTLEEAK DLVAFCKAHN ILLIPEFDMP
GHSGAFVRTF RHDMQSPEGM KILKLLVDEV CETFDVPYLH IGTDEVRFTN PKFVPEMVEY
VRAKGKKVIS WNPGWHYKPG EIDMTHLWSY RGKAQKGIPA IDSKFHYLNH FDTFGDIIAL
YNSRIYNVEQ GSDDIAGTIL AIWNDRYVAN ERNIILENNF YPNMLAIAER AWKGGGTEYF
DKNGTILPSE GSPEFKEFAD FENRMLWHKE HTFKGYPFAY VKQTNVKWNI TDAFPNGGDL
NKVFPPEQEL KDSYLYEGKE YGVHPAIGAG IYLRHVWGKM VPTFYKDPQE NHTAYAYTWV
YSPKDQEVGL WAEFQNYGRS EMDLAPLQGK WDYKGSRIWI NNEEIQPPVW TATHRTKSNE
IALGNENCVA RPPIAVHLNK GWNKVFLKLP VGKFNMPEVR LVKWMFTTVF VTPDGENAVD
GLIYSPDKTK
//
