ID   Q5LFN6_BACFN            Unreviewed;       428 AA.
AC   Q5LFN6; A0A380YWU2;
DT   21-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   21-JUN-2005, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   SubName: Full=O-acetylhomoserine sulfhydrylase {ECO:0000313|EMBL:CAH07057.1};
DE            EC=2.5.1.49 {ECO:0000313|EMBL:CAH07057.1};
GN   Name=metY {ECO:0000313|EMBL:CAH07057.1};
GN   ORFNames=BF9343_1276 {ECO:0000313|EMBL:CAH07057.1};
OS   Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS   / NCTC 9343 / Onslow).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=272559 {ECO:0000313|EMBL:CAH07057.1, ECO:0000313|Proteomes:UP000006731};
RN   [1] {ECO:0000313|EMBL:CAH07057.1, ECO:0000313|Proteomes:UP000006731}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 /
RC   Onslow {ECO:0000313|Proteomes:UP000006731};
RX   PubMed=15746427; DOI=10.1126/science.1107008;
RA   Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V.,
RA   Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A.,
RA   Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A.,
RA   Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J.,
RA   Barrell B.G., Parkhill J.;
RT   "Extensive DNA inversions in the B. fragilis genome control variable gene
RT   expression.";
RL   Science 307:1463-1465(2005).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; CR626927; CAH07057.1; -; Genomic_DNA.
DR   RefSeq; WP_010992441.1; NZ_UFTH01000001.1.
DR   PaxDb; 272559-BF9343_1276; -.
DR   KEGG; bfs:BF9343_1276; -.
DR   eggNOG; COG2873; Bacteria.
DR   HOGENOM; CLU_018986_4_0_10; -.
DR   BioCyc; BFRA272559:G1GHZ-1373-MONOMER; -.
DR   Proteomes; UP000006731; Chromosome.
DR   GO; GO:0018826; F:methionine gamma-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006731};
KW   Transferase {ECO:0000313|EMBL:CAH07057.1}.
FT   MOD_RES         210
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   428 AA;  46089 MW;  23A3EC8E84552EA4 CRC64;
     METKKLHFET LQLHVGQETP DPATDARAVP IYQTTSYVFR DSAHAAARFG LQDPGNIYGR
     LTNSTQGVLE ERIAALEGGV GGLAVASGAA AVTYAIENIT RSGDHIVAAK TIYGGTYNLL
     AHTLPAYGVT TTFVDPSDLF NFERAIRENT KAIFIETLGN PNSNIIDMDA VAAIAHKYRI
     PLIVDNTFGT PYLIRPIEHG ADIVVHSATK FIGGHGSSLG GVIVDSGKFD WVASGKFPQL
     TEPDASYHGV RFVDAAGAAA YIVRIRAVLL RDTGAAISPF NAFILLQGLE TLSLRVERHV
     ANALKVIDFL VNHPKVAAVN HPSLPGHPDH AIYQRYFPGG AGSIFTFEVK GGTEEAQKFI
     DSLQIFSLLA NVADVKSLVI HPGTTTHSQL NAQELEEQGI KPGTVRLSIG TEHIEDIIDD
     LRQALEKI
//