ID   Q5NFT7_FRATT            Unreviewed;       592 AA.
AC   Q5NFT7; A0A0G2RMW9;
DT   01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   01-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   SubName: Full=Type IV pili nucleotide binding protein, ABC transporter, ATP-binding protein {ECO:0000313|EMBL:CAG45766.1};
GN   Name=pilB {ECO:0000313|EMBL:CAG45766.1};
GN   OrderedLocusNames=FTT_1133 {ECO:0000313|EMBL:CAG45766.1};
OS   Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=177416 {ECO:0000313|EMBL:CAG45766.1, ECO:0000313|Proteomes:UP000001174};
RN   [1] {ECO:0000313|EMBL:CAG45766.1, ECO:0000313|Proteomes:UP000001174}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCHU S4 / Schu 4 {ECO:0000313|Proteomes:UP000001174};
RX   PubMed=15640799; DOI=10.1038/ng1499;
RA   Larsson P., Oyston P.C.F., Chain P., Chu M., Duffield M., Fuxelius H.H.,
RA   Garcia E., Halltorp G., Johansson D., Isherwood K., Karp P., Larsson E.,
RA   Lui Y., Michell S., Prior J., Prior R., Sjostedt A., Svensson K.,
RA   Thompson N., Vergez L., Wagg J., Wren B., Lindler L.E., Andersson S.G.,
RA   Forsman M., Titball R.W.;
RT   "The complete genome sequence of Francisella tularensis, the causative
RT   agent of tularemia.";
RL   Nat. Genet. 37:153-159(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the GSP E family.
CC       {ECO:0000256|ARBA:ARBA00006611}.
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DR   EMBL; AJ749949; CAG45766.1; -; Genomic_DNA.
DR   RefSeq; WP_003021324.1; NZ_CP010290.1.
DR   RefSeq; YP_170105.1; NC_006570.2.
DR   AlphaFoldDB; Q5NFT7; -.
DR   IntAct; Q5NFT7; 1.
DR   DNASU; 3191922; -.
DR   EnsemblBacteria; CAG45766; CAG45766; FTT_1133.
DR   KEGG; ftu:FTT_1133; -.
DR   PATRIC; fig|177416.36.peg.1692; -.
DR   OrthoDB; 6189814at2; -.
DR   Proteomes; UP000001174; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR   CDD; cd01129; PulE-GspE-like; 1.
DR   Gene3D; 3.30.450.90; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.30.300.160; Type II secretion system, protein E, N-terminal domain; 1.
DR   InterPro; IPR013374; ATPase_typ4_pilus-assembl_PilB.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001482; T2SS/T4SS_dom.
DR   InterPro; IPR037257; T2SS_E_N_sf.
DR   InterPro; IPR007831; T2SS_GspE_N.
DR   NCBIfam; TIGR02538; type_IV_pilB; 1.
DR   PANTHER; PTHR30258:SF1; PROTEIN TRANSPORT PROTEIN HOFB HOMOLOG; 1.
DR   PANTHER; PTHR30258; TYPE II SECRETION SYSTEM PROTEIN GSPE-RELATED; 1.
DR   Pfam; PF05157; MshEN; 1.
DR   Pfam; PF00437; T2SSE; 1.
DR   SUPFAM; SSF160246; EspE N-terminal domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00662; T2SP_E; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:CAG45766.1};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001174}.
FT   DOMAIN          398..412
FT                   /note="Bacterial type II secretion system protein E"
FT                   /evidence="ECO:0000259|PROSITE:PS00662"
SQ   SEQUENCE   592 AA;  66924 MW;  9F31289D421FB6AF CRC64;
     MIENPHICKK LASLLLHRKL ITKQQLEEIS HDKSLAKQDF LEYLIENEIV DSKSFMIESA
     TLLRLQYIDL TTINVKFLPQ EYFDIDFCRE NHCLALFTRK RTIHVAIANP IESQQILKKL
     RSRYDCAFIP VVAELNHLKE KIEEYEQYLK DEGQREDDAK LNERIDAGSE LDIDFVEEGE
     REGDAIIGSG EDEEAPIIRF INNTIVDAIQ KGASDIHFEP YEKNFRIRYR IDGLLIETFN
     TKKNLAPKVI SRLKIMSSLD IAEKRIPQDG KFKISLSREK AIDFRVSTCP ISFGEKVVLR
     IIDSSSTQIP IEQLGFSESQ KETYLKYIQQ PQGMVLVTGP TGSGKTVTLY TGINILNKPE
     KNISTAEDPV ELIVKGINQV SVNNKQGLTF AAALKSFLRQ DPDIIMVGEI RDIETGSIAI
     KASQTGHLVM STLHTNSAPE TLNRLVDMGL PRYNIATSVT LIIAQRLTRK LCPKCKLPDT
     DTEFSLLVED SGLNDEILAK TFGTTLDKVK NAKIYKANPK GCPRCFKGYK GRIGLYEVMP
     VSRQISRMIL EDKNTMEIAI QAQKEGIATV RQSALVRVAE DLTSMEEAYR VS
//