ID   Q5P8H7_AROAE            Unreviewed;       639 AA.
AC   Q5P8H7;
DT   04-JAN-2005, integrated into UniProtKB/TrEMBL.
DT   04-JAN-2005, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN   ORFNames=ebA511 {ECO:0000313|EMBL:CAI06382.1};
OS   Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales;
OC   Rhodocyclaceae; Aromatoleum.
OX   NCBI_TaxID=76114 {ECO:0000313|EMBL:CAI06382.1, ECO:0000313|Proteomes:UP000006552};
RN   [1] {ECO:0000313|EMBL:CAI06382.1, ECO:0000313|Proteomes:UP000006552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EbN1 {ECO:0000313|EMBL:CAI06382.1,
RC   ECO:0000313|Proteomes:UP000006552};
RX   PubMed=15551059; DOI=10.1007/s00203-004-0742-9;
RA   Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F.,
RA   Reinhardt R.;
RT   "The genome sequence of an anaerobic aromatic-degrading denitrifying
RT   bacterium, strain EbN1.";
RL   Arch. Microbiol. 183:27-36(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
CC         Evidence={ECO:0000256|ARBA:ARBA00024557};
CC   -!- SIMILARITY: Belongs to the bacterial reverse transcriptase family.
CC       {ECO:0000256|ARBA:ARBA00034120}.
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DR   EMBL; CR555306; CAI06382.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5P8H7; -.
DR   STRING; 76114.ebA511; -.
DR   KEGG; eba:ebA511; -.
DR   eggNOG; COG0265; Bacteria.
DR   eggNOG; COG3344; Bacteria.
DR   HOGENOM; CLU_034461_0_0_4; -.
DR   OrthoDB; 7055795at2; -.
DR   Proteomes; UP000006552; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd03487; RT_Bac_retron_II; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR000123; Reverse_transcriptase_msDNA.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR34047; NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR34047:SF7; RNA-DIRECTED DNA POLYMERASE; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00866; RNADNAPOLMS.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:CAI06382.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006552};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:CAI06382.1};
KW   Transferase {ECO:0000313|EMBL:CAI06382.1}.
FT   DOMAIN          30..262
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          613..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        621..639
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   639 AA;  71303 MW;  895CBC502B07A1F1 CRC64;
     MAILLSLDQI VEALVRSEPA SFSRDVLGMP YDSLKAIIYP RPPYKSFTIK KRDGSDRTIF
     EPRKRLKVIQ LKVLDFLQKR STPLKPAVHG FVAKRSILTN AQVHCSPKNH HIFNIDLEDF
     FPSITFYRVR GVLLHHPFKF SHEVATVIAH ICTLDKTLPQ GAPTSPFLSN LVCRTLDRDL
     TELARRCLAR YSRYADDITF SFRTRKTIKL PAAICSVDSD GDTVIGTELH DIIVNQHHFK
     INSAKTRLCD RNRRMEVTGL TINQFPNVPR VFIDRIRGAL IAWESHGYAA ANKVWNERVT
     AARSGAYEKK PWKRQTRRGQ VPDLKNVLWG KLLYLRMVRG KDDLIYTRLA ERYNSAVLIT
     AATGTFTAPK LPVEPVVRDK ETARDACFVV EWMGDYDEPG VGTEVPISQG TAFVYRELNL
     LVTCNHVLEW QNGEEGKFLA QIDYESPFLS DKALKLIQPG TKKSWDAKIL YRNEQMDFAL
     LAFEDPPQHR YFSAMDNPIE PGAKGFLIGY PAWKQWNLAD VNSQTVLNRT SPHAGMNSFT
     ITGAGSIRPG NSGGPFTDDR FRVAGMAQRG AYMGDGHDEN LCIEIIDELI AAYKASLVAP
     AVLVPAASAA APASPATAAP SAKPTAPPPA PTPPPPVMP
//