ID Q5QNN0_DANRE Unreviewed; 340 AA.
AC Q5QNN0; A0A8M1NCH4;
DT 04-JAN-2005, integrated into UniProtKB/TrEMBL.
DT 04-JAN-2005, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Trace amine-associated receptor 12i {ECO:0000313|Ensembl:ENSDARP00000105073, ECO:0000313|RefSeq:NP_001076554.1};
GN Name=taar12i {ECO:0000313|Ensembl:ENSDARP00000105073,
GN ECO:0000313|RefSeq:NP_001076554.1,
GN ECO:0000313|ZFIN:ZDB-GENE-041014-61};
GN Synonyms=si:dkey-7c18.15 {ECO:0000313|RefSeq:NP_001076554.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000105073};
RN [1] {ECO:0000313|RefSeq:NP_001076554.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001076554.1};
RX PubMed=19237578;
RA Hussain A., Saraiva L.R., Korsching S.I.;
RT "Positive Darwinian selection and the birth of an olfactory receptor clade
RT in teleosts.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:4313-4318(2009).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000105073, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000105073};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000105073}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000105073};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001076554.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001076554.1};
RX PubMed=26519734;
RA Li Q., Tachie-Baffour Y., Liu Z., Baldwin M.W., Kruse A.C., Liberles S.D.;
RT "Non-classical amine recognition evolved in a large clade of olfactory
RT receptors.";
RL Elife 4:E10441-E10441(2015).
RN [5] {ECO:0000313|RefSeq:NP_001076554.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001076554.1};
RX PubMed=26108469;
RA Saraiva L.R., Ahuja G., Ivandic I., Syed A.S., Marioni J.C.,
RA Korsching S.I., Logan D.W.;
RT "Molecular and neuronal homology between the olfactory systems of zebrafish
RT and mouse.";
RL Sci. Rep. 5:11487-11487(2015).
RN [6] {ECO:0000313|RefSeq:NP_001076554.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001076554.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AL929507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001076554.1; NM_001083085.1.
DR Ensembl; ENSDART00000126495; ENSDARP00000105073; ENSDARG00000086268.
DR Ensembl; ENSDART00000126495.2; ENSDARP00000105073.1; ENSDARG00000086268.2.
DR GeneID; 100034543; -.
DR KEGG; dre:100034543; -.
DR AGR; ZFIN:ZDB-GENE-041014-61; -.
DR CTD; 100034543; -.
DR ZFIN; ZDB-GENE-041014-61; taar12i.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_0_1; -.
DR OMA; VIRVIMY; -.
DR OrthoDB; 2901788at2759; -.
DR PhylomeDB; Q5QNN0; -.
DR TreeFam; TF343107; -.
DR Reactome; R-DRE-375280; Amine ligand-binding receptors.
DR Reactome; R-DRE-418555; G alpha (s) signalling events.
DR Proteomes; UP000000437; Alternate scaffold 20.
DR Proteomes; UP000000437; Chromosome 20.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IDA:ZFIN.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR PANTHER; PTHR24249; HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24249:SF220; TRACE AMINE-ASSOCIATED RECEPTOR 4; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:NP_001076554.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..309
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 340 AA; 38450 MW; 1358081CD6DCC8E5 CRC64;
MTSNETDVYA ENMFLCFPHL PNSCPKSQRF VVVKLAMYVC LLLMILTTVF GNLLIIISIS
HFKHLQSPTH LIVRSLAASD CLLGSLVMPY SMVRSVEGCW YLGDVVCKVH SSLDMTFCIS
SLLHLGLVSI DRYWAICDPL RYRIRVTNTT VTLYTIFIWL FSFLYSFVIV FSGVNRIGLE
TFIMQVYCVG SCVLFFNKEW GLICPVLTFF IPGAIMSSLY MKIFHVARKH AKVMSERVTG
GLKSQSSAQR ERKAAKTLAI VMGVFLLCWT PIFIASIIDS FLNFVTPAGV FDALIWFGYF
NSTCNPLIYG FFYSCFQKAF KILLSSLFLG FGNSSTLTFE
//
