ID DCA11_PONAB Reviewed; 546 AA.
AC Q5R7H5; Q5REE4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=DDB1- and CUL4-associated factor 11;
DE AltName: Full=WD repeat-containing protein 23;
GN Name=DCAF11; Synonyms=WDR23;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex, and Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC ubiquitin-protein ligase complex. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Interacts with DDB1 and CUL4A. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH92285.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CR857585; CAH89863.1; -; mRNA.
DR EMBL; CR860141; CAH92285.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001126335.1; NM_001132863.1.
DR RefSeq; NP_001128756.1; NM_001135284.1.
DR AlphaFoldDB; Q5R7H5; -.
DR SMR; Q5R7H5; -.
DR STRING; 9601.ENSPPYP00000006460; -.
DR Ensembl; ENSPPYT00000006715.3; ENSPPYP00000006460.3; ENSPPYG00000005680.3.
DR GeneID; 100173316; -.
DR GeneID; 100189652; -.
DR KEGG; pon:100173316; -.
DR CTD; 80344; -.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00720000108873; -.
DR HOGENOM; CLU_014280_3_1_1; -.
DR InParanoid; Q5R7H5; -.
DR OMA; MMSHFLP; -.
DR OrthoDB; 5667at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001595; Chromosome 14.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR017399; DCAF11/LEC14B.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19847; DDB1- AND CUL4-ASSOCIATED FACTOR 11; 1.
DR PANTHER; PTHR19847:SF7; DDB1- AND CUL4-ASSOCIATED FACTOR 11; 1.
DR Pfam; PF00400; WD40; 4.
DR PIRSF; PIRSF038135; WD_repeat_p23; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway;
KW WD repeat.
FT CHAIN 1..546
FT /note="DDB1- and CUL4-associated factor 11"
FT /id="PRO_0000373803"
FT REPEAT 170..210
FT /note="WD 1"
FT REPEAT 216..258
FT /note="WD 2"
FT REPEAT 263..302
FT /note="WD 3"
FT REPEAT 305..345
FT /note="WD 4"
FT REPEAT 353..392
FT /note="WD 5"
FT REPEAT 435..480
FT /note="WD 6"
FT REPEAT 481..520
FT /note="WD 7"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 75
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91VU6"
SQ SEQUENCE 546 AA; 61631 MW; 0A332CE531048692 CRC64;
MGSRNSSSAG SGSGDPSEGL TRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG
GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD TRELECNEIK TQVELATGQL
GLRRAAQKHS FPRMLHQRER GLCHRGSFSL GEQSRVISHF LPNDLGFTDS YSQKAFCGIY
SKDGQIFMSA CQDQTIRLYD CRYGRFRKFK SIKARDVGWS VLDVAFTPDG SHFLYSSWSD
YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT
LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF
IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA TQQNWDYRWQ QVPKKAWRKL
KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT
NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESEECAS APAPVPRSST
PFSSPQ
//
