ID Q5SJ23_THET8 Unreviewed; 575 AA.
AC Q5SJ23;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Penicillin-binding protein 2/cell division protein FtsI {ECO:0000313|EMBL:BAD71014.1};
GN OrderedLocusNames=TTHA1191 {ECO:0000313|EMBL:BAD71014.1};
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852 {ECO:0000313|EMBL:BAD71014.1, ECO:0000313|Proteomes:UP000000532};
RN [1] {ECO:0000313|EMBL:BAD71014.1, ECO:0000313|Proteomes:UP000000532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8 {ECO:0000313|Proteomes:UP000000532};
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:6PL5, ECO:0007829|PDB:6PL6}
RP X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 2-575, AND DISULFIDE BONDS.
RX PubMed=32152588; DOI=10.1038/s41564-020-0687-z;
RA Sjodt M., Rohs P.D.A., Gilman M.S.A., Erlandson S.C., Zheng S., Green A.G.,
RA Brock K.P., Taguchi A., Kahne D., Walker S., Marks D.S., Rudner D.Z.,
RA Bernhardt T.G., Kruse A.C.;
RT "Structural coordination of polymerization and crosslinking by a SEDS-bPBP
RT peptidoglycan synthase complex.";
RL Nat. Microbiol. 5:813-820(2020).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; AP008226; BAD71014.1; -; Genomic_DNA.
DR RefSeq; WP_011173259.1; NC_006461.1.
DR RefSeq; YP_144457.1; NC_006461.1.
DR PDB; 6PL5; X-ray; 3.50 A; B=2-575.
DR PDB; 6PL6; X-ray; 3.30 A; B=2-575.
DR PDBsum; 6PL5; -.
DR PDBsum; 6PL6; -.
DR AlphaFoldDB; Q5SJ23; -.
DR SMR; Q5SJ23; -.
DR EnsemblBacteria; BAD71014; BAD71014; BAD71014.
DR GeneID; 3168510; -.
DR KEGG; ttj:TTHA1191; -.
DR PATRIC; fig|300852.9.peg.1172; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_0; -.
DR PhylomeDB; Q5SJ23; -.
DR Proteomes; UP000000532; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6PL5, ECO:0007829|PDB:6PL6};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000532}.
FT DOMAIN 48..199
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 250..568
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DISULFID 332..364
FT /evidence="ECO:0007829|PDB:6PL5, ECO:0007829|PDB:6PL6"
SQ SEQUENCE 575 AA; 62925 MW; 6227B34650316345 CRC64;
MTGRIHALAL FFALALFLLG LRAWQLQVLE YERYALRSQG NYLKTEDIPA PRGKILDRKG
RVLAQDRLVV DLVYTGGEVA FKERLLPLLG LEDLPQVTEP TVLKAGVPEA LRPTLEELTA
GQKNLYLRER IERYYPNPIS GPVMGYVLRA NAAQVKQGYS PEEEVGQAGL EAALEPYLRG
KRGVRAVEVN VRGERLRETV LEEPTPGQDV VLTLDLALQR AAEKALEEAL ADINAGRRLN
GLPEEKQVKG AIVALDPTTG EVLAMASAPS FDPNLFAKRP VPEEAKALLE DKNLPLLNRA
VQPYTPGSTF KLATSYALLE EGYVTPATTY RCSPYIVFGG QVRRNWASRD MGPMTVREAI
AWSCNTWYYQ AVAQDPLGFV DRLARRARLL GLGEATGLEV AEKTGLLPTR AWKREALGEP
WYPGETLSVA IGQGAVLATP AQIARMLATI ATGGNKPALH LVKAIGGVPV QPRWEKVPGR
YWKVLQEGLR KTVSEGTARF VLGEFPVPTG GKTGTAETPG KRRGLEHAWY MGYGPTDGSP
YPPLVVVAFF ENGGEGSRVA LPAVRKVMAA YWGIK
//