ID Q5SV54_MOUSE Unreviewed; 1104 AA.
AC Q5SV54;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=Ortholog of human amyotrophic lateral sclerosis 2 (Juvenile) chromosome region, candidate 19 (ALS2CR19) {ECO:0000313|EMBL:CAI24823.1};
DE SubName: Full=Par-3 family cell polarity regulator beta {ECO:0000313|Ensembl:ENSMUSP00000092510.3};
GN Name=Pard3b {ECO:0000313|Ensembl:ENSMUSP00000092510.3,
GN ECO:0000313|MGI:MGI:1919301};
GN Synonyms=Als2cr19 {ECO:0000313|MGI:MGI:1919301}, RP23-20G7.1
GN {ECO:0000313|EMBL:CAI24823.1};
GN ORFNames=RP23-20G7.1-003 {ECO:0000313|EMBL:CAI24823.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:CAI24823.1};
RN [1] {ECO:0000313|EMBL:CAI24823.1}
RP NUCLEOTIDE SEQUENCE.
RA Babbage A.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000092510.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000092510.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000092510.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000092510.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL645669; CAI24823.1; -; Genomic_DNA.
DR EMBL; AL645544; CAI24823.1; JOINED; Genomic_DNA.
DR EMBL; AL645727; CAI24823.1; JOINED; Genomic_DNA.
DR EMBL; AL662815; CAI24823.1; JOINED; Genomic_DNA.
DR EMBL; AL662920; CAI24823.1; JOINED; Genomic_DNA.
DR ProteomicsDB; 330551; -.
DR Antibodypedia; 34169; 41 antibodies from 18 providers.
DR Ensembl; ENSMUST00000094906.4; ENSMUSP00000092510.3; ENSMUSG00000052062.15.
DR AGR; MGI:1919301; -.
DR MGI; MGI:1919301; Pard3b.
DR VEuPathDB; HostDB:ENSMUSG00000052062; -.
DR GeneTree; ENSGT00950000183214; -.
DR HOGENOM; CLU_006629_0_0_1; -.
DR ChiTaRS; Pard3b; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000052062; Expressed in rostral migratory stream and 193 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 2.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF4; PARTITIONING DEFECTIVE 3 HOMOLOG B; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 2.
PE 1: Evidence at protein level;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Proteomics identification {ECO:0007829|MaxQB:Q5SV54,
KW ECO:0007829|PeptideAtlas:Q5SV54};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 383..468
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 496..573
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 79..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..851
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..925
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1066
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 121781 MW; 9674D72D059119B1 CRC64;
MKVTVCFGRT GIVVPCKDGQ LRVRELTQQA LQRYLKTRDQ DPGYWVKIHH LEYTDGGILD
PDDVLADVVE DKDKLIAVFD EQEPLQKTES PGGNPADRQS PDAFETEVAA QLAAFKPVGG
EIVVTPSALK LGTPLLVRRS SDPAPGPHAD AQPSTASLSG QSLKPVVLDS TQNVENKEAM
NGEQAGLLSL HRPKDELSDM TRAVEISGEG DPLGIHVVPF FSSLSGRILG LFIRGIEENS
RCKQEGLFQE NECIVKINNV ELLDKTFAQA QDVFRQAMKS PSVILHVLLP QNREQYEKSV
IGPLNIFGNN DGASRTKAAP PARGKPGLKA VHLTRASSPE GEEPASPQQS KSPRVPRLGR
KPSSPSLSPL MGFGSKKNAK KIKIDLKKGP EGLGFTVVTR DSSIHGPGPI FVKNILPKGA
AVKDGRLQSG DRILEVNGRD VTGRTQEELV AMLRSTKQGE TVSLVIARQE GSFLPRELKG
EPDCYALSLE SSEQLTLEIP LNDSGSAGLG VSLKGNKSRE TGTDLGIFIK SIIHGGAAFK
DGRLRMNDQL IAVNGETLLG KSNHEAMETL RRSMSMEGNI RGMIQLVILR RPERPLEELS
ECGALSRPGF ENCQEALSTS RRNDSSILYP FGTYSPQDKR KDLLLPSDGW AENEVPPSPP
PHPALEWGLE DFSHSSGVDS TGYFPDQHVN FRTVTPVRQP ELINLKASKS MDLVPDEGKV
QSLADRRSDS PGKDFGPTLG LKKSSSLESL QTAVAEVRKN DLPFHRPRPH MVRGRGCNES
FRAAIDKSYD GPEEADADGL SDKSSRSGHT ALNCESAPQG NPELDNVENK AKNIKKTKEK
EKKKGKGKLK VKEKKLKEEH EDAERKMKRK GFGAMLRFGK KKDDKVGKAE QKGAQKSGHP
EEEELERMKE ERESGRPMAG TTDRIQKLRK EYYQARREGF LLYEDENTRA RPSDHDLRWV
SGKGPDGSTH NLRFEGMERQ YASLPRGGSA DPVDYLTASP RGRYNDRELP YYPGPHPVHA
PRGSYPRPPD LRATDLRYPQ YYPPPPAHQH KGPFRQDVPP SPPQHQRVPV YQEMGRAGPR
GSSPDQYPYR NQDPRQKNPM TAAV
//
