ID Q5SXX7_HUMAN Unreviewed; 147 AA.
AC Q5SXX7;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=ethanolamine kinase {ECO:0000256|ARBA:ARBA00038874};
DE EC=2.7.1.82 {ECO:0000256|ARBA:ARBA00038874};
DE Flags: Fragment;
GN Name=ETNK2 {ECO:0000313|Ensembl:ENSP00000406241.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000406241.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000406241.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000406241.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00037883}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
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DR EMBL; AL592146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q5SXX7; -.
DR SMR; Q5SXX7; -.
DR MassIVE; Q5SXX7; -.
DR PeptideAtlas; Q5SXX7; -.
DR ProteomicsDB; 64005; -.
DR Antibodypedia; 34553; 195 antibodies from 25 providers.
DR Ensembl; ENST00000444817.1; ENSP00000406241.1; ENSG00000143845.15.
DR UCSC; uc057oqg.1; human.
DR HGNC; HGNC:25575; ETNK2.
DR VEuPathDB; HostDB:ENSG00000143845; -.
DR GeneTree; ENSGT00950000182939; -.
DR HOGENOM; CLU_1772298_0_0_1; -.
DR ChiTaRS; ETNK2; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000143845; Expressed in right testis and 118 other cell types or tissues.
DR ExpressionAtlas; Q5SXX7; baseline and differential.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR PANTHER; PTHR22603:SF94; ETHANOLAMINE KINASE 2; 1.
DR Pfam; PF01633; Choline_kinase; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q5SXX7,
KW ECO:0007829|ProteomicsDB:Q5SXX7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000406241.1"
FT NON_TER 147
FT /evidence="ECO:0000313|Ensembl:ENSP00000406241.1"
SQ SEQUENCE 147 AA; 17218 MW; 2F2BC89B1DE0C825 CRC64;
YGERTELLVD RENEVRNFQL LRAHSCAPKL YCTFQNGLCY EYMQGVALEP EHIREPRLFS
LSADVPKVEV LERELAWLKE HLSQLESPVV FCHNDLLCKN IIYDSIKGHV RFIDYEYAGY
NYQAFDIGNH FNEFAGVNEV DYCLYPA
//
