ID Q5SYU9_HUMAN Unreviewed; 283 AA.
AC Q5SYU9;
DT 21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 21-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Sarcosine dehydrogenase {ECO:0000313|Ensembl:ENSP00000360933.1};
GN Name=SARDH {ECO:0000313|Ensembl:ENSP00000360933.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000360933.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000360933.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000360933.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL365494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q5SYU9; -.
DR SMR; Q5SYU9; -.
DR MassIVE; Q5SYU9; -.
DR MaxQB; Q5SYU9; -.
DR PeptideAtlas; Q5SYU9; -.
DR ProteomicsDB; 64037; -.
DR Antibodypedia; 31926; 86 antibodies from 17 providers.
DR Ensembl; ENST00000371867.5; ENSP00000360933.1; ENSG00000123453.19.
DR UCSC; uc064wwf.1; human.
DR HGNC; HGNC:10536; SARDH.
DR VEuPathDB; HostDB:ENSG00000123453; -.
DR GeneTree; ENSGT00940000157589; -.
DR HOGENOM; CLU_983394_0_0_1; -.
DR ChiTaRS; SARDH; human.
DR Proteomes; UP000005640; Chromosome 9.
DR Bgee; ENSG00000123453; Expressed in right lobe of liver and 112 other cell types or tissues.
DR ExpressionAtlas; Q5SYU9; baseline and differential.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 2.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR13847:SF200; SARCOSINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q5SYU9,
KW ECO:0007829|MaxQB:Q5SYU9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 5..245
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
SQ SEQUENCE 283 AA; 31058 MW; 724E5B2C58EAC5F4 CRC64;
MSGAVLLERE RLTSGTTWHT AGLLWQLRPS DVEVELLAHT RRVVSRELEE ETGLHTGWIQ
NGGLFIASNR QRLDEYKRLM SLGKAYGVES HVLSPAETKT LYPLMNVDDL YGTLYVPHDG
TMDPAGTCTT LARAASARGA QVIENCPVTG IRVWTDDFGV RRVAGVETQH GSIQTPCVVN
CAGVWASAVG RMAGVKVPLV AMHHAYVVTE RIEGIQNMPN VRDHDASVYL RLQGDALSVG
GYEANPIFWE EAVKYRPRAA GGLCLKTSTE KVCAVWSDDL RRA
//
