ID Q5U4R7_XENLA Unreviewed; 266 AA.
AC Q5U4R7;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=H6 family homeobox 2 S homeolog {ECO:0000313|RefSeq:NP_001088574.1};
DE SubName: Full=LOC495452 protein {ECO:0000313|EMBL:AAH84979.1};
GN Name=hmx2.L {ECO:0000313|Xenbase:XB-GENE-17338938};
GN Synonyms=hmx2 {ECO:0000313|RefSeq:NP_001088574.1}, hmx2.S
GN {ECO:0000313|RefSeq:NP_001088574.1}, LOC495452
GN {ECO:0000313|EMBL:AAH84979.1}, nkx5.2
GN {ECO:0000313|RefSeq:NP_001088574.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH84979.1};
RN [1] {ECO:0000313|RefSeq:NP_001088574.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH84979.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAH84979.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001088574.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the HMX homeobox family.
CC {ECO:0000256|ARBA:ARBA00038165}.
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DR EMBL; BC084979; AAH84979.1; -; mRNA.
DR RefSeq; NP_001088574.1; NM_001095105.1.
DR DNASU; 495452; -.
DR GeneID; 495452; -.
DR KEGG; xla:495452; -.
DR AGR; Xenbase:XB-GENE-17338938; -.
DR AGR; Xenbase:XB-GENE-865340; -.
DR CTD; 495452; -.
DR Xenbase; XB-GENE-17338938; hmx2.L.
DR OrthoDB; 414754at2759; -.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 495452; Expressed in neurula embryo and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR46110; HOMEOBOX PROTEIN HMX; 1.
DR PANTHER; PTHR46110:SF4; HOMEOBOX PROTEIN HMX2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 141..201
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 143..202
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 266 AA; 30021 MW; AC007DEABB3F04EA CRC64;
MSTKEEPTKP TPGTLSSFTI QSILQGTTSD RGRNVARVYT RETISCQQSS PSTSSDEEEQ
DESWTVYGCN CHDPGDKDSK GQAPNPCGAH RCPNRTQGSL PSNKRLQMPS PSQKDYTEEK
DSHYPQSLGE RHKDVGDNMG NSKKKTRTVF SRSQVYQLES TFDMKRYLSS SERSCLASSL
QLTETQVKTW FQNRRNKWKR QLSAELEAAN MAHASAQTLV GMPLVFRDNS ILRVPVPRSI
AFPAPLYYPT SNVSLPLYNL YNKMEY
//
