ID   Q5UFH9_MYCTX            Unreviewed;       186 AA.
AC   Q5UFH9;
DT   07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   07-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE            EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE   AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
DE   Flags: Fragment;
GN   Name=pncA {ECO:0000313|EMBL:AAV33192.1};
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773 {ECO:0000313|EMBL:AAV33192.1};
RN   [1] {ECO:0000313|EMBL:AAV33192.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=14 {ECO:0000313|EMBL:AAV33192.1};
RA   Sheen P., Mendez M., Gilman R., Calla J., Lopez C., Evangelista W.,
RA   Zimic M.;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC       from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC   -!- SIMILARITY: Belongs to the isochorismatase family.
CC       {ECO:0000256|ARBA:ARBA00006336}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY743300; AAV33192.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5UFH9; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   PANTHER; PTHR11080:SF2; LD05707P; 1.
DR   PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642}.
FT   DOMAIN          3..182
FT                   /note="Isochorismatase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00857"
FT   NON_TER         186
FT                   /evidence="ECO:0000313|EMBL:AAV33192.1"
SQ   SEQUENCE   186 AA;  19606 MW;  A928138E4C6A222B CRC64;
     MRALTIVDVQ NDFCEGGSLA VTGGAALARA ISDYLAEAAD YHHVVATKKF HIDPGDHFSG
     TPDYSSSWPP HCVSGTPGAD FHPSLDTSAI EAVFYKGAYT GAYSGFEGVD ENGTPLLNWL
     RQRGVDEVDV VGIATDHCVR QTAEDAVRNG LATRVLVDLT AGVSADTTVA ALEEMRTASV
     ELVCSS
//