ID Q5V649_HALMA Unreviewed; 196 AA.
AC Q5V649;
DT 07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT 07-DEC-2004, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=TetR family transcriptional regulator {ECO:0000313|EMBL:QCP89975.1};
DE SubName: Full=Transcription regulator {ECO:0000313|EMBL:AAV45003.1};
GN Name=tetR {ECO:0000313|EMBL:AAV45003.1};
GN OrderedLocusNames=pNG7308 {ECO:0000313|EMBL:AAV45003.1};
GN ORFNames=E6P14_03590 {ECO:0000313|EMBL:QCP89975.1};
OS Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS B-1809) (Halobacterium marismortui).
OG Plasmid pHMA411 {ECO:0000313|EMBL:QCP89975.1},
OG Plasmid pNG700 {ECO:0000313|EMBL:AAV45003.1,
OG ECO:0000313|Proteomes:UP000001169}, and
OG Plasmid phma411 {ECO:0000313|Proteomes:UP000298722}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Haloarcula.
OX NCBI_TaxID=272569 {ECO:0000313|EMBL:AAV45003.1, ECO:0000313|Proteomes:UP000001169};
RN [1] {ECO:0000313|EMBL:AAV45003.1, ECO:0000313|Proteomes:UP000001169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 {ECO:0000313|EMBL:AAV45003.1}, and ATCC 43049 / DSM
RC 3752 / JCM 8966 / VKM B-1809 {ECO:0000313|Proteomes:UP000001169};
RC PLASMID=Plasmid pNG700 {ECO:0000313|Proteomes:UP000001169}, and pNG700
RC {ECO:0000313|EMBL:AAV45003.1};
RX PubMed=15520287; DOI=10.1101/gr.2700304;
RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA Hood L., Ng W.V.;
RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT Dead Sea.";
RL Genome Res. 14:2221-2234(2004).
RN [2] {ECO:0007829|PDB:3CRJ}
RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS).
RA Tan K., Zhou M., Freeman L., Joachimiak A.;
RT "The crystal structure of a TetR transcription regulator from Haloarcula
RT marismortui ATCC 43049.";
RL Submitted (APR-2008) to the PDB data bank.
RN [3] {ECO:0000313|EMBL:QCP89975.1, ECO:0000313|Proteomes:UP000298722}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43049 {ECO:0000313|EMBL:QCP89975.1,
RC ECO:0000313|Proteomes:UP000298722};
RC PLASMID=pHMA411 {ECO:0000313|EMBL:QCP89975.1}, and phma411
RC {ECO:0000313|Proteomes:UP000298722};
RA DasSarma S., DasSarma P., DasSarma S., Fomenkov A., Vincze T., Anton B.P.,
RA Roberts R.J.;
RT "Methylomes of two halophilic Archaea, Haloarcula marismortui and Haloferax
RT mediterranei.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AY596296; AAV45003.1; -; Genomic_DNA.
DR EMBL; CP039137; QCP89975.1; -; Genomic_DNA.
DR RefSeq; WP_004966015.1; NZ_CP039137.1.
DR PDB; 3CRJ; X-ray; 2.60 A; A/B/C/D=1-196.
DR PDBsum; 3CRJ; -.
DR AlphaFoldDB; Q5V649; -.
DR SMR; Q5V649; -.
DR EnsemblBacteria; AAV45003; AAV45003; pNG7308.
DR GeneID; 64825244; -.
DR KEGG; hma:pNG7308; -.
DR PATRIC; fig|272569.17.peg.735; -.
DR HOGENOM; CLU_069356_15_3_2; -.
DR EvolutionaryTrace; Q5V649; -.
DR Proteomes; UP000001169; Plasmid pNG700.
DR Proteomes; UP000298722; Plasmid phma411.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR47506:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATOR YJDC; 1.
DR PANTHER; PTHR47506; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3CRJ};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00335}; Plasmid {ECO:0000313|EMBL:AAV45003.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001169};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 10..70
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 196 AA; 22440 MW; 0491F9C7C1853F25 CRC64;
MAGPSDRTFS DQTEEIMQAT YRALREHGYA DLTIQRIADE YGKSTAAVHY YYDTKDDLLA
AFLDYLLERF VDSIHDVETT DPEARLNLLL DELLVKPQEN PDLSVALLEM RSQAPYKEAF
SDRFRQNDEY VRYMLKAVIN HGIDEGVFTD VDAEHVTRSL LTIIDGARTR AVMLDDTEEL
ETARQTASEY ADAMLQ
//
