ID DC122_HUMAN Reviewed; 463 AA.
AC Q5VW00; B2RN42;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 150.
DE RecName: Full=DDB1- and CUL4-associated factor 12-like protein 2;
DE AltName: Full=WD repeat-containing protein 40C;
GN Name=DCAF12L2; Synonyms=WDR40C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the WD repeat DCAF12 family. {ECO:0000305}.
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DR EMBL; AL445072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471107; EAX11842.1; -; Genomic_DNA.
DR EMBL; BC136673; AAI36674.1; -; mRNA.
DR EMBL; BC136674; AAI36675.1; -; mRNA.
DR CCDS; CCDS43991.1; -.
DR RefSeq; NP_001013650.1; NM_001013628.2.
DR AlphaFoldDB; Q5VW00; -.
DR SMR; Q5VW00; -.
DR BioGRID; 131079; 18.
DR IntAct; Q5VW00; 11.
DR STRING; 9606.ENSP00000353128; -.
DR iPTMnet; Q5VW00; -.
DR PhosphoSitePlus; Q5VW00; -.
DR BioMuta; DCAF12L2; -.
DR DMDM; 74756914; -.
DR jPOST; Q5VW00; -.
DR MassIVE; Q5VW00; -.
DR MaxQB; Q5VW00; -.
DR PaxDb; 9606-ENSP00000353128; -.
DR PeptideAtlas; Q5VW00; -.
DR ProteomicsDB; 65506; -.
DR Antibodypedia; 68425; 83 antibodies from 14 providers.
DR DNASU; 340578; -.
DR Ensembl; ENST00000360028.4; ENSP00000353128.2; ENSG00000198354.7.
DR GeneID; 340578; -.
DR KEGG; hsa:340578; -.
DR MANE-Select; ENST00000360028.4; ENSP00000353128.2; NM_001013628.3; NP_001013650.1.
DR UCSC; uc004euk.3; human.
DR AGR; HGNC:32950; -.
DR CTD; 340578; -.
DR GeneCards; DCAF12L2; -.
DR HGNC; HGNC:32950; DCAF12L2.
DR HPA; ENSG00000198354; Tissue enhanced (epididymis).
DR neXtProt; NX_Q5VW00; -.
DR OpenTargets; ENSG00000198354; -.
DR PharmGKB; PA165756531; -.
DR VEuPathDB; HostDB:ENSG00000198354; -.
DR eggNOG; ENOG502QR7U; Eukaryota.
DR GeneTree; ENSGT00940000161322; -.
DR HOGENOM; CLU_020124_1_0_1; -.
DR InParanoid; Q5VW00; -.
DR OMA; PRYSHIR; -.
DR OrthoDB; 23695at2759; -.
DR PhylomeDB; Q5VW00; -.
DR TreeFam; TF323731; -.
DR PathwayCommons; Q5VW00; -.
DR SignaLink; Q5VW00; -.
DR BioGRID-ORCS; 340578; 8 hits in 800 CRISPR screens.
DR GenomeRNAi; 340578; -.
DR Pharos; Q5VW00; Tdark.
DR PRO; PR:Q5VW00; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5VW00; Protein.
DR Bgee; ENSG00000198354; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 103 other cell types or tissues.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19860:SF8; DDB1- AND CUL4-ASSOCIATED FACTOR 12-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR19860; DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..463
FT /note="DDB1- and CUL4-associated factor 12-like protein 2"
FT /id="PRO_0000306850"
FT REPEAT 89..137
FT /note="WD 1"
FT REPEAT 138..184
FT /note="WD 2"
FT REPEAT 185..252
FT /note="WD 3"
FT REPEAT 253..297
FT /note="WD 4"
FT REPEAT 298..341
FT /note="WD 5"
FT REPEAT 342..401
FT /note="WD 6"
FT REPEAT 402..445
FT /note="WD 7"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 147
FT /note="H -> Q (in dbSNP:rs10126452)"
FT /id="VAR_062104"
SQ SEQUENCE 463 AA; 50803 MW; 94B41809F2243CD7 CRC64;
MAQQQTGSRK RKAPAVEAGA GSSSSQGLAA ADGEGPLLPK KQKRPATRRR LVHYLKGREV
GARGPAGLQG FEGELRGYAV QRLPELLTER QLDLGTLNKV FASQWLNARQ VVCGTKCNTL
FVVDVQSGHI TRIPLMRDKE AGLAQAHQGC GIHAIELNPS KTLLATGGEN PNSLAIYQLP
TLDPLCLGDR HGHKDWIFAV AWLSDTVAVS GSRDGTVALW RMDPDMFNGS IAWHSEVGLP
VYAHIRPRDV EAIPRASTNP SNRKVRALAF SGKNQELGAV SLDGYFHLWK ARSTLSRLLS
IRLPYCRENV CLTYCDELSL YAVGSQSHVS FLDPRQRQQN IRPLCSREGG TGVRSLSFYQ
HIITVGTGHG SLLFYDIRAQ KFLEERASSS LDSMPGPAGR KLKLACGRGW LNQDDVWVNY
FGGMGEFPNA LYTHCYNWPE MKLFVAGGPL PSGLHGNYAG LWS
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