ID Q5XCL0_STRP6 Unreviewed; 301 AA.
AC Q5XCL0;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Transcriptional regulators, LysR family {ECO:0000313|EMBL:AAT86853.1};
GN OrderedLocusNames=M6_Spy0718 {ECO:0000313|EMBL:AAT86853.1};
OS Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=286636 {ECO:0000313|EMBL:AAT86853.1, ECO:0000313|Proteomes:UP000001167};
RN [1] {ECO:0000313|EMBL:AAT86853.1, ECO:0000313|Proteomes:UP000001167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-946 / MGAS10394 {ECO:0000313|Proteomes:UP000001167};
RX PubMed=15272401; DOI=10.1086/422697;
RA Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT "Progress toward characterization of the group A Streptococcus metagenome:
RT complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL J. Infect. Dis. 190:727-738(2004).
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000256|ARBA:ARBA00009437}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000003; AAT86853.1; -; Genomic_DNA.
DR RefSeq; WP_002984924.1; NC_006086.1.
DR AlphaFoldDB; Q5XCL0; -.
DR GeneID; 69901000; -.
DR KEGG; spa:M6_Spy0718; -.
DR HOGENOM; CLU_039613_32_2_9; -.
DR Proteomes; UP000001167; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd05466; PBP2_LTTR_substrate; 1.
DR Gene3D; 3.40.190.290; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30346:SF16; SMALL NEUTRAL PROTEASE REGULATORY PROTEIN; 1.
DR PANTHER; PTHR30346; TRANSCRIPTIONAL DUAL REGULATOR HCAR-RELATED; 1.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
FT DOMAIN 1..58
FT /note="HTH lysR-type"
FT /evidence="ECO:0000259|PROSITE:PS50931"
SQ SEQUENCE 301 AA; 34678 MW; ACB4AAEBE0469AE0 CRC64;
MRIQQLHYII KIVECGSMNE AAKQLFITQP SLSNAVKDLE MEMGITIFNR NPKGITLTKD
GVEFLSYARQ IIEQTSLLED RYKNHNTGRE LFSVSSQHYA FVVNAFVSLL KRTDMTRYEL
FLRETRTWEI IDDVKNFRSE IGVLFINDYN RDVLTKLFDD NHLTASPLFK AQPHIFVSKS
NPLATKSLLS MDDLRDFPYL SYDQGIHNSF YFSEEMMSQM PHNKSIVVSD RATLFNLMIG
LDGYTVASGI LNSNLNGDQI VAIPLDVPDE IDIVFIKHEK ANLSKMGERF IEYLLEEVTF
D
//
