ID Q5XDX9_STRP6 Unreviewed; 304 AA.
AC Q5XDX9;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=N-acetylneuraminate lyase {ECO:0000313|EMBL:AAT86384.1};
DE EC=4.1.3.3 {ECO:0000313|EMBL:AAT86384.1};
GN OrderedLocusNames=M6_Spy0249 {ECO:0000313|EMBL:AAT86384.1};
OS Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=286636 {ECO:0000313|EMBL:AAT86384.1, ECO:0000313|Proteomes:UP000001167};
RN [1] {ECO:0000313|EMBL:AAT86384.1, ECO:0000313|Proteomes:UP000001167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-946 / MGAS10394 {ECO:0000313|Proteomes:UP000001167};
RX PubMed=15272401; DOI=10.1086/422697;
RA Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT "Progress toward characterization of the group A Streptococcus metagenome:
RT complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL J. Infect. Dis. 190:727-738(2004).
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; CP000003; AAT86384.1; -; Genomic_DNA.
DR RefSeq; WP_011184155.1; NC_006086.1.
DR AlphaFoldDB; Q5XDX9; -.
DR KEGG; spa:M6_Spy0249; -.
DR HOGENOM; CLU_049343_6_0_9; -.
DR Proteomes; UP000001167; Chromosome.
DR GO; GO:0008747; F:N-acetylneuraminate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR42849; N-ACETYLNEURAMINATE LYASE; 1.
DR PANTHER; PTHR42849:SF1; N-ACETYLNEURAMINATE LYASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT ACT_SITE 139
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 167
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 209
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 304 AA; 33178 MW; 6D1FB6EAD4FC1280 CRC64;
MTDLTKYQGI IPAFYACYDD QGAISPERVR ALTQYYIDKG VQGLYINGSS GECIYQSVFD
RQLVLENVMA VAKGKLTIIN HVACNNTKDS IELAAHSERL GVDAIAAIPP IYFRLPEYAV
ADYWNAISSA APHTDFIIYN IPQLAGVALT PSLYKTMLAN KRVIGVKNSS MPVQDIQTFC
AIGGDDRIVF NGPDEQFLGG RLMGAAAGIG GTYGAMPELF LRLNQLIAHK DLEKAKALQY
TINEIIGVLV SAHGNMYGVI KEVLRINEGL DIGSVRSPLA ELVEEDRVIC QRAAALINQA
KETF
//
