ID   Q5YPS4_NOCFA            Unreviewed;       868 AA.
AC   Q5YPS4;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   OrderedLocusNames=NFA_49650 {ECO:0000313|EMBL:BAD59817.1};
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD59817.1, ECO:0000313|Proteomes:UP000006820};
RN   [1] {ECO:0000313|EMBL:BAD59817.1, ECO:0000313|Proteomes:UP000006820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD59817.1,
RC   ECO:0000313|Proteomes:UP000006820};
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; AP006618; BAD59817.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5YPS4; -.
DR   STRING; 247156.NFA_49650; -.
DR   KEGG; nfa:NFA_49650; -.
DR   eggNOG; COG0642; Bacteria.
DR   HOGENOM; CLU_002554_1_0_11; -.
DR   OrthoDB; 4652229at2; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR   PANTHER; PTHR44936:SF12; SENSOR PROTEIN CREC; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAD59817.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006820};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        299..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          502..612
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   REGION          611..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          776..868
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        623..653
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   868 AA;  92703 MW;  C477AAD50FEA9E89 CRC64;
     MDAAPRSRQF SLSNWPVTRK VGIVLLLPVV LASTFAVLRI NDELRTIADL DAATDQARII
     RPMLEFASAT EQLAVVTATV WENDEGAVDR AGTRFDQAAV DLQTVLRSGG APEDVINELD
     EAVTTGRTMR NSLRSSSPVS IGQQADQVAA HIGNAIARST SLEEISIQRY FLQLGVTTNA
     RRLLTQQYLL IGSPGAERNP AVRPTVLTTA GGELVLLSQY AQLQPASALN ANILIDAVNV
     RLGAFAQNIE NPASSQPVID SLRTSVKAYD ESTLSLVDAI DNRLADRTAD VRGVVLRDIA
     IVVTTLLAGL ALALAVARSL VLPIRRLRHG ALQVAHVDLP NELEVVRSGG ATPEPTRVDV
     HTTEEIGQLA RAVDDIHGAA LHLAAEQARL RLQIGSMFET LSRRSQSLVE QQLSLIEELE
     HDEDDSQRLQ SLFRLDHLAT RMRRNGDNLL VLAGTALRRG HLPPVPLSDM LWSAVSQVED
     YQRVEIGAAP DGVVPGEPAV DIEHLLAELI DNALRYSPPT TSVAVSVARS VDGGYLIEII
     DRGLGMSAED LQTVNSHLAS GGEVTVETAR RMGLFVVGRL AKRHNITVNL RRTSAMTQQP
     GITASVHLPG SLVTAVPPND KHPQELLAPP PMPEPSYDAP SQPTPPRILV PVPSPALPEH
     TSSFELSGSG LPQRRPAIRV APAPEREAGR PGTEAPEPAP GRPLDPPAHT GSFPAEPTKV
     DVWAEAEPDA YEAAGYEPAE PAQPAQTTMT GLRPVNAESP TPIYQRMVSE WLVEPASSGS
     EGEGGGWSSP GDIGWAAAAE ASKPQVSGRT NGGLPIRRPG AQLVPGGLAP TNESNARDPE
     EIRNSLTRHL SGVRSGRADA QYNDGGLE
//