ID Q5YQ69_NOCFA Unreviewed; 543 AA.
AC Q5YQ69;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Adenylate cyclase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=NFA_48200 {ECO:0000313|EMBL:BAD59672.1};
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD59672.1, ECO:0000313|Proteomes:UP000006820};
RN [1] {ECO:0000313|EMBL:BAD59672.1, ECO:0000313|Proteomes:UP000006820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD59672.1,
RC ECO:0000313|Proteomes:UP000006820};
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; AP006618; BAD59672.1; -; Genomic_DNA.
DR RefSeq; WP_011211356.1; NC_006361.1.
DR AlphaFoldDB; Q5YQ69; -.
DR STRING; 247156.NFA_48200; -.
DR GeneID; 61135417; -.
DR KEGG; nfa:NFA_48200; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG2770; Bacteria.
DR HOGENOM; CLU_025433_2_1_11; -.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006820};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 234..286
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 318..441
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 487..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 58277 MW; A96E900FC9C5D18F CRC64;
MIAKLVVWAL KARWGLAAVV ITANMTGLAV IVTQLWLSGF LGRLGPDWRH TLTMVAVYPI
IGLLIGVGLA VRDRNVYFRW LNEARKPTPE EARKVLRLPI AITARALALW IPGVIIATSM
FSQFTPHNNT AVTAALFTLG AFESAAVTFL IVDRLIRPTI PVVARVLGAT MHWSSSVLVR
VVVTWAVSGA MPLVMLIVVL ADPAAGAPDR IRTAIYLSGV GIAVGALATT FLARSVATPM
RTLRLALDRI SKGETDVRVP VGSASEVGRL EHSVNELAAN LRERDRMRDV FGRHVGAEVA
ERALAGGLDL TGDVRVVSAL FVDVTGSVAL STELAPQEFV AKLNRLLSIV VAATEDNNGL
VNKFEGDAAL CIFGAPIALR DNATPALRAA RRIRDEVTAI GELDIGIGVA RGQVFAGDVG
TDTRLEYTVI GDAVNEAARL TAEAKRVPRR ILVSRALIEA AAPHERVKWT AYRHILLRGM
PVPTATWTDI ETPARPSPCE DRWKTTGDGA ESGTGHGSRR LPMSGMTEIR AATPQHEQPD
GPP
//