ID Q5YW21_NOCFA Unreviewed; 487 AA.
AC Q5YW21;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Putative succinate-semialdehyde dehydrogenase {ECO:0000313|EMBL:BAD57620.1};
GN Name=gabD {ECO:0000313|EMBL:BAD57620.1};
GN OrderedLocusNames=NFA_27730 {ECO:0000313|EMBL:BAD57620.1};
OS Nocardia farcinica (strain IFM 10152).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD57620.1, ECO:0000313|Proteomes:UP000006820};
RN [1] {ECO:0000313|EMBL:BAD57620.1, ECO:0000313|Proteomes:UP000006820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD57620.1,
RC ECO:0000313|Proteomes:UP000006820};
RX PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA Shiba T., Hattori M.;
RT "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; AP006618; BAD57620.1; -; Genomic_DNA.
DR RefSeq; WP_011209305.1; NC_006361.1.
DR AlphaFoldDB; Q5YW21; -.
DR STRING; 247156.NFA_27730; -.
DR GeneID; 61133508; -.
DR KEGG; nfa:NFA_27730; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_1_11; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000006820; Chromosome.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07103; ALDH_F5_SSADH_GabD; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR43353; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43353:SF5; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000006820}.
FT DOMAIN 22..481
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 487 AA; 51791 MW; 3D0228F0645973B5 CRC64;
MTDREGALLA TAPHQLFIGG EWVDATGGAT FAVHDPATGE IVREVADATA EDAVRALDAA
VAAQESWAAT APRTRGEILR RAWELVQERA EDLALLMTLE MGKPLAEARG EVTYGGEFLR
WFSEEAVRIH GRYGLNPEGT GQMIVSQRPV GPCYFITPWN FPFAMATRKI APALAAGCTV
VVKPPQLTPL TTLFFTGLLA EAGLPAGVVN VVTSTSSRRV SAPIIADSRL RKLSFTGSTE
VGRQLIAQAA DNVLRVSMEL GGNAPFVVFE DADLDKAVEG ALAAKFRNIG QACTAANRFI
VHEQVAEEFA ARVTERVAAM KIGRGTEDGV TIGPLIDDDA VAKAHELVTD ATARGAVVRT
GGERIDGPGS FYRPTVLTGV TEGSAILREE IFGPVLAIAT FTTEDEAVRL ANNTEYGLVS
YVYTRDLARG HRMIDKLETG MMGLNAGVVS NAAAPFGGVK QSGVGREGGF EGIHEFLSTK
YTLIPTS
//
