ID Q5ZJ03_CHICK Unreviewed; 71 AA.
AC Q5ZJ03;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE RecName: Full=Guanine nucleotide-binding protein subunit gamma {ECO:0000256|RuleBase:RU004973};
GN Name=GNG2 {ECO:0000313|Ensembl:ENSGALP00010028072.1};
GN ORFNames=RCJMB04_22c19 {ECO:0000313|EMBL:CAG32290.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAG32290.1};
RN [1] {ECO:0000313|EMBL:CAG32290.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CB {ECO:0000313|EMBL:CAG32290.1};
RC TISSUE=Bursa {ECO:0000313|EMBL:CAG32290.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2] {ECO:0000313|Ensembl:ENSGALP00010028072.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010028072.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction. {ECO:0000256|RuleBase:RU004973}.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma.
CC {ECO:0000256|RuleBase:RU004973}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU004973};
CC Lipid-anchor {ECO:0000256|RuleBase:RU004973}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU004973}.
CC -!- SIMILARITY: Belongs to the G protein gamma family.
CC {ECO:0000256|ARBA:ARBA00007431, ECO:0000256|RuleBase:RU004973}.
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DR EMBL; AJ720631; CAG32290.1; -; mRNA.
DR RefSeq; NP_001090997.1; NM_001097528.1.
DR STRING; 9031.ENSGALP00000043053; -.
DR PaxDb; 9031-ENSGALP00000043053; -.
DR Ensembl; ENSGALT00010047375.1; ENSGALP00010028072.1; ENSGALG00010019634.1.
DR GeneID; 423581; -.
DR KEGG; gga:423581; -.
DR CTD; 54331; -.
DR VEuPathDB; HostDB:geneid_423581; -.
DR eggNOG; KOG4119; Eukaryota.
DR GeneTree; ENSGT01100000263497; -.
DR HOGENOM; CLU_168377_0_1_1; -.
DR OMA; GKQQPPM; -.
DR OrthoDB; 2872810at2759; -.
DR TreeFam; TF319909; -.
DR Reactome; R-GGA-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-GGA-202040; G-protein activation.
DR Reactome; R-GGA-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-GGA-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-GGA-4086398; Ca2+ pathway.
DR Reactome; R-GGA-416476; G alpha (q) signalling events.
DR Reactome; R-GGA-416482; G alpha (12/13) signalling events.
DR Reactome; R-GGA-418217; G beta:gamma signalling through PLC beta.
DR Reactome; R-GGA-418555; G alpha (s) signalling events.
DR Reactome; R-GGA-418592; ADP signalling through P2Y purinoceptor 1.
DR Reactome; R-GGA-418594; G alpha (i) signalling events.
DR Reactome; R-GGA-418597; G alpha (z) signalling events.
DR Reactome; R-GGA-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-GGA-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-GGA-500657; Presynaptic function of Kainate receptors.
DR Reactome; R-GGA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-GGA-8964315; G beta:gamma signalling through BTK.
DR Reactome; R-GGA-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-GGA-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-GGA-9634597; GPER1 signaling.
DR Reactome; R-GGA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000027629; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809:SF25; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-2; 1.
DR PANTHER; PTHR13809; GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU004973};
KW Lipoprotein {ECO:0000256|RuleBase:RU004973};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004973};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q5ZJ03};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU004973}.
FT DOMAIN 5..71
FT /note="G protein gamma"
FT /evidence="ECO:0000259|PROSITE:PS50058"
SQ SEQUENCE 71 AA; 7878 MW; EDB7515135E7A37A CRC64;
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL LTPVPASENP
FREKKFFCVI L
//
