ID Q5ZU41_LEGPH Unreviewed; 188 AA.
AC Q5ZU41;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Transcriptional regulator, TetR family {ECO:0000313|EMBL:AAU28036.1};
GN OrderedLocusNames=lpg1967 {ECO:0000313|EMBL:AAU28036.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU28036.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU28036.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
RN [2] {ECO:0007829|PDB:3ON4}
RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
RA Michalska K., Li H., Gu M., Joachimiak A.;
RT "Crystal structure of TetR transcriptional regulator from Legionella
RT pneumophila.";
RL Submitted (AUG-2010) to the PDB data bank.
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DR EMBL; AE017354; AAU28036.1; -; Genomic_DNA.
DR RefSeq; YP_095983.1; NC_002942.5.
DR PDB; 3ON4; X-ray; 1.85 A; A/B/C/D/E/F/G/H=1-188.
DR PDBsum; 3ON4; -.
DR AlphaFoldDB; Q5ZU41; -.
DR SMR; Q5ZU41; -.
DR STRING; 272624.lpg1967; -.
DR PaxDb; 272624-lpg1967; -.
DR DNASU; 3078466; -.
DR KEGG; lpn:lpg1967; -.
DR PATRIC; fig|272624.6.peg.2059; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_28_4_6; -.
DR OrthoDB; 9809772at2; -.
DR EvolutionaryTrace; Q5ZU41; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR47506:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR LMRA; 1.
DR PANTHER; PTHR47506; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3ON4};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000000609}.
FT DOMAIN 6..66
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 29..48
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 188 AA; 20928 MW; 8E5222ACFF698847 CRC64;
MPMNISNTKE RILAVAEALI QKDGYNAFSF KDIATAINIK TASIHYHFPS KEDLGVAVIS
WHTDKIAAVL SDISNNSSLS AKEKIQKFFD AILTLTYNSE NKMCLGGMFA SDFQSLPVSI
QNQAKKFFEL IIEWLKGVLE TNGYDNESSL SLAKQIISLV EGGLLLARLY GDETFLEGVR
HFIDQTIK
//
