ID Q5ZUQ4_LEGPH Unreviewed; 768 AA.
AC Q5ZUQ4;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Adenylate/guanylate cyclase transmembrane protein {ECO:0000313|EMBL:AAU27818.1};
DE EC=4.6.1.1 {ECO:0000313|EMBL:AAU27818.1};
GN Name=gidA {ECO:0000313|EMBL:AAU27818.1};
GN OrderedLocusNames=lpg1739 {ECO:0000313|EMBL:AAU27818.1};
OS Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS 33152 / DSM 7513).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU27818.1, ECO:0000313|Proteomes:UP000000609};
RN [1] {ECO:0000313|EMBL:AAU27818.1, ECO:0000313|Proteomes:UP000000609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC {ECO:0000313|Proteomes:UP000000609};
RX PubMed=15448271; DOI=10.1126/science.1099776;
RA Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA Russo J.J.;
RT "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL Science 305:1966-1968(2004).
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DR EMBL; AE017354; AAU27818.1; -; Genomic_DNA.
DR RefSeq; YP_095765.1; NC_002942.5.
DR AlphaFoldDB; Q5ZUQ4; -.
DR SMR; Q5ZUQ4; -.
DR STRING; 272624.lpg1739; -.
DR PaxDb; 272624-lpg1739; -.
DR KEGG; lpn:lpg1739; -.
DR PATRIC; fig|272624.6.peg.1822; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG4252; Bacteria.
DR HOGENOM; CLU_000445_85_1_6; -.
DR OrthoDB; 9806704at2; -.
DR Proteomes; UP000000609; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR007890; CHASE2.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF05226; CHASE2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM01080; CHASE2; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:AAU27818.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000609};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:AAU27818.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 513..645
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 768 AA; 86822 MW; 7908C73FEE4CF918 CRC64;
MINKEDALSS WFKSSKRIIF VNKLTLYFPQ FLNHIKWTEF FLGLTVTLLV LLTLFFNIPP
LNSLISQFEG RIYDQIINFN WHSKPENLKV IIIDIDEKSL EQEGRWPWPR SKIAELLNKL
QENGVVTVGF DIVMSEAETN YALGLIEKLS QFSGKMTTDQ KQLIATLNSV ANQVDNDQTL
VNALGKNNAI LGFFFHNSEG IRKGSLPTPL RDTDSNPLLA NKLSVYQFTN FNGNLAAFTA
AATSGGFVTN LPDKDGVVRH ALLLANYKNN LYPSLSLAIA MNYLLTDKVA LKKYNNQLIG
IELDGLQIPT NRKGQILIPF WGGPGTLNYY SATDILNNQF NPEELAGSIA LVGSSITLLS
DLHHTPVAQL FPGVEIVGNI VKGLVEQKIP REFDWESLQG KLCLVIFGLL FALVFSSVGI
FGKLLIFFIT TIVILTNTVI LFVFYNNYIP PAFLLTITTL QTFVNFSYSY VIEKRQKRRI
SELFGQYVPK EYVKELIEHP EHHTMEGLNR EMTVLFTDIR NFTTISETLG AGGVKLLLNS
FFTPMTKIIF EHRGTIDKYV GDMIVAFWGA PIEDKEHASH AVLCSLSCFE HLPQINTHLL
EHGLPQVNIG VGIATGPMNV GDMGSEFRRA YTVLGDTVNL ASRLESLTKF YQVNILVSDK
TRSYLDSILW RTVDKVAVKG RKSPLTIYQP LGIVEQASAR LLQEQEKYET ALAHYYNQDW
LAAEIIFNEL KNVNPKIYLY QMYLERIAAF KKKRPLPDWD GVYVHRSK
//
