ID Q603N4_METCA Unreviewed; 401 AA.
AC Q603N4;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=2-octaprenyl-6-methoxyphenol hydroxylase {ECO:0000313|EMBL:AAU91139.1};
DE EC=1.14.13.- {ECO:0000313|EMBL:AAU91139.1};
GN Name=ubiH {ECO:0000313|EMBL:AAU91139.1};
GN OrderedLocusNames=MCA2769 {ECO:0000313|EMBL:AAU91139.1};
OS Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylococcus.
OX NCBI_TaxID=243233 {ECO:0000313|EMBL:AAU91139.1, ECO:0000313|Proteomes:UP000006821};
RN [1] {ECO:0000313|EMBL:AAU91139.1, ECO:0000313|Proteomes:UP000006821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33009 / NCIMB 11132 / Bath
RC {ECO:0000313|Proteomes:UP000006821};
RX PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J.,
RA Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L.,
RA Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H.,
RA Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R.,
RA Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.;
RT "Genomic insights into methanotrophy: the complete genome sequence of
RT Methylococcus capsulatus (Bath).";
RL PLoS Biol. 2:1616-1628(2004).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the UbiH/COQ6 family.
CC {ECO:0000256|ARBA:ARBA00005349}.
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DR EMBL; AE017282; AAU91139.1; -; Genomic_DNA.
DR RefSeq; WP_010961972.1; NC_002977.6.
DR AlphaFoldDB; Q603N4; -.
DR STRING; 243233.MCA2769; -.
DR KEGG; mca:MCA2769; -.
DR eggNOG; COG0654; Bacteria.
DR HOGENOM; CLU_009665_8_1_6; -.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000006821; Chromosome.
DR GO; GO:0008681; F:2-octaprenyl-6-methoxyphenol hydroxylase activity; ISS:JCVI.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; ISS:JCVI.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR018168; Ubi_Hdrlase_CS.
DR InterPro; IPR011295; UbiH.
DR InterPro; IPR010971; UbiH/COQ6.
DR NCBIfam; TIGR01988; Ubi-OHases; 1.
DR NCBIfam; TIGR01984; UbiH; 1.
DR PANTHER; PTHR43876; UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43876:SF7; UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS01304; UBIH; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AAU91139.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006821}.
FT DOMAIN 5..342
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 401 AA; 43048 MW; 8B7972F420BF72DB CRC64;
MTNFDYDVLI IGGGLAGGCL ALALAGSPLK VAVVESSTEA ERQAAPAGAR ALALARGTAR
ILETLGVWAA VEPKATPIRH IHVSDRGHFG KTRLSAEREG VAALGYVATA RDVEDAVIGA
LHAGSVELIQ PARLIGLRAG PDSVHVSLRR GEEALTLSAR LVVGADGSDS TVRRLLEIPQ
IVREYGQTAL VFEVSCELEH RNVAYERFTS SGPLAVLPLG RRRCSVVWTL APSDAEELRA
VPEGEFLARL QDAFGYWLGT LGPVGPRQGF PLRLIRGGRM ADDRVVLIGN AMHQLHPVAG
QGFNLGLRDA ARLAERLIVK QGFGEDIGDP AFLHSYAEAR QRDLGSTVAF TDSLIRLFSS
DFPPLALMRN IGLLTLDCLP PAKHLLARHA MGLAERLPRF R
//
