ID Q603T0_METCA Unreviewed; 365 AA.
AC Q603T0;
DT 23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Putative heavy metal efflux system protein {ECO:0000313|EMBL:AAU91214.1};
GN OrderedLocusNames=MCA2719 {ECO:0000313|EMBL:AAU91214.1};
OS Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylococcus.
OX NCBI_TaxID=243233 {ECO:0000313|EMBL:AAU91214.1, ECO:0000313|Proteomes:UP000006821};
RN [1] {ECO:0000313|EMBL:AAU91214.1, ECO:0000313|Proteomes:UP000006821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33009 / NCIMB 11132 / Bath
RC {ECO:0000313|Proteomes:UP000006821};
RX PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J.,
RA Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L.,
RA Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H.,
RA Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R.,
RA Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.;
RT "Genomic insights into methanotrophy: the complete genome sequence of
RT Methylococcus capsulatus (Bath).";
RL PLoS Biol. 2:1616-1628(2004).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; AE017282; AAU91214.1; -; Genomic_DNA.
DR RefSeq; WP_010961928.1; NC_002977.6.
DR AlphaFoldDB; Q603T0; -.
DR STRING; 243233.MCA2719; -.
DR KEGG; mca:MCA2719; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_13_0_6; -.
DR Proteomes; UP000006821; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; ISS:JCVI.
DR GO; GO:0030001; P:metal ion transport; ISS:JCVI.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30097; CATION EFFLUX SYSTEM PROTEIN CUSB; 1.
DR PANTHER; PTHR30097:SF4; SLR6042 PROTEIN; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006821};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..365
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004266036"
FT DOMAIN 53..278
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 365 AA; 39796 MW; 53E1CCE733203F08 CRC64;
MKLALFPAVI SLLTAPALAA DTLVKMDAQQ IEHLDVRVAK PEIVNALPLA WAPARVVIPP
DREFIVSAPQ AGVITRIDVA LGSSVAPGQV VAEMQSPDLL TLQRDLLNAA TEYELAGSKL
NRDQKLLDEG VISKLRWQET RSTFDKAQAN LRQAEQVLDA SGMSAKDIAE LKRTRSISNT
LLLRTPIRGV LLERLATVGQ RVSMLAPLFR IGNVDQLWLE IDMPQERLSE IRLKDRVELD
SPRIRATIIE VSQNVRPDSQ TALVRAVIDE HDDSVRAGQN VNVQVMHAST DFICRVPLAA
IISQDGRQYV FVRTSDGFAV RPVKVAAVDG RQAIIHEGLT ADDRVAVQGV AALKGAWTGL
GGGDE
//
