ID Q63JA3_BURPS Unreviewed; 529 AA.
AC Q63JA3;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Non-ribosomal peptide synthase {ECO:0000313|EMBL:CAH39291.1};
GN OrderedLocusNames=BPSS1815 {ECO:0000313|EMBL:CAH39291.1};
OS Burkholderia pseudomallei (strain K96243).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=272560 {ECO:0000313|EMBL:CAH39291.1, ECO:0000313|Proteomes:UP000000605};
RN [1] {ECO:0000313|EMBL:CAH39291.1, ECO:0000313|Proteomes:UP000000605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K96243 {ECO:0000313|EMBL:CAH39291.1,
RC ECO:0000313|Proteomes:UP000000605};
RX PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.M., Atkins T.,
RA Crossman L.C., Pitt T., Churcher C., Mungall K., Bentley S.D., Sebaihia M.,
RA Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F.,
RA Challis G.L., Cherevach I., Chillingworth T., Cronin A., Crosset B.,
RA Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H.,
RA Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C.,
RA Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S.,
RA Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT pseudomallei.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
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DR EMBL; BX571966; CAH39291.1; -; Genomic_DNA.
DR RefSeq; WP_004533314.1; NZ_CP009537.1.
DR RefSeq; YP_111819.1; NC_006351.1.
DR AlphaFoldDB; Q63JA3; -.
DR STRING; 272560.BPSS1815; -.
DR KEGG; bps:BPSS1815; -.
DR PATRIC; fig|272560.51.peg.5258; -.
DR eggNOG; COG1020; Bacteria.
DR Proteomes; UP000000605; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000605};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..372
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 427..505
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 529 AA; 58168 MW; FBE169B3D39A9909 CRC64;
MARHIVQAIQ SHAFATPYKC ALSDSRGDLG YADLDSFSTR FAMRLQDLGC RPGDRVVMLA
SRRALLVAAI IGVFKAGCVH VPLDPRMPAD RLRYILHDVA PTLVIADEDL IDAIEHALPA
AAPIVPVTEL ERLLDDADSP RLDALVQPLP LPPLDERAIA YCIYTSGSTG RPKGVLINHR
SIADFFEGTR AVYDVTAQSR CASFSPLNFD VYLMDMLFPL AQGASLYVHD DVNAPDLLFD
AIRAHDVTHF SAWGMMLGLI AQAEEFEAAP LPHLKTILTG TDVPDVKTVQ RWLRKNAGVQ
VINAYGPTEA TCAATAHVIR EIEPERRTLY PIGKPLEHVL ALLVDEGGNR ITAPGVPGEL
MIGGTQVMQG YWNLPEETAA RLVRLDGVPF YRTGDVCAYL ADGSLYYMGR KDNEVKIGGY
RIHLSEIQRV INSVPHVYGS EVVLLESRYG ETLLAAGVLL ERGAPLDADC KADEIRQRLA
AELPAYMVPR HVKVLEQFPQ LSSGKTDRKA LLSILQQRIN ESNQEEVNP
//
