ID Q63UA2_BURPS Unreviewed; 386 AA.
AC Q63UA2;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Threonine aldolase {ECO:0000313|EMBL:CAH35713.1};
GN OrderedLocusNames=BPSL1714 {ECO:0000313|EMBL:CAH35713.1};
OS Burkholderia pseudomallei (strain K96243).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=272560 {ECO:0000313|EMBL:CAH35713.1, ECO:0000313|Proteomes:UP000000605};
RN [1] {ECO:0000313|EMBL:CAH35713.1, ECO:0000313|Proteomes:UP000000605}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K96243 {ECO:0000313|EMBL:CAH35713.1,
RC ECO:0000313|Proteomes:UP000000605};
RX PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.M., Atkins T.,
RA Crossman L.C., Pitt T., Churcher C., Mungall K., Bentley S.D., Sebaihia M.,
RA Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F.,
RA Challis G.L., Cherevach I., Chillingworth T., Cronin A., Crosset B.,
RA Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H.,
RA Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C.,
RA Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S.,
RA Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT pseudomallei.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
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DR EMBL; BX571965; CAH35713.1; -; Genomic_DNA.
DR RefSeq; WP_004527001.1; NZ_CP009538.1.
DR RefSeq; YP_108314.1; NC_006350.1.
DR AlphaFoldDB; Q63UA2; -.
DR SMR; Q63UA2; -.
DR STRING; 272560.BPSL1714; -.
DR GeneID; 56529397; -.
DR KEGG; bps:BPSL1714; -.
DR PATRIC; fig|272560.6.peg.1923; -.
DR eggNOG; COG2008; Bacteria.
DR Proteomes; UP000000605; Chromosome 1.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR023603; Low_specificity_L-TA-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; NF041359; GntG_guanitoxin; 1.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF017617; Thr_aldolase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000605}.
FT DOMAIN 33..318
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 231
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR017617-1"
SQ SEQUENCE 386 AA; 40513 MW; 42B1F556463CCB50 CRC64;
MTRTTAAAKA AVSTTNRRSE AGRPNQWIDA MIDFLSDTVT LPTAEMRHAM FTANVGDDCY
GEDPTVNELE SVAAGLTGKE AAAFVTSGTL GNLSALLAQC PRGHEVILGD RSDLYNYEAG
GVSLVGGAVL HPVETADDGS LPLERLRAAI RDKRDPQCAP AAVIALENPH CLAGGRVLSL
DYLRRVRALA DEHGLAVHMD GARLFNAQAS LGTPAAEIVA HVDSVQFCLS KSLAAPYGSM
VCGSAALIDR VKRYRKLLGG GTRQAGIMAA AGLVALRTMV ARLADDHRRA ARLAAELARI
PGVALRSAVI ETNMVFFDVA EPGNEAFLAA LRDAGIRMGV LGDGVIRAVV HYMIDDDAIS
RTVDAVRAIV LPFAPALAPA AASQAQ
//
