ID Q640H6_XENLA Unreviewed; 809 AA.
AC Q640H6;
DT 25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=LOC494672 protein {ECO:0000313|EMBL:AAH82649.1};
DE SubName: Full=Leucine rich repeat containing 8 VRAC subunit A L homeolog {ECO:0000313|RefSeq:NP_001087987.1};
GN Name=lrrc8a.L {ECO:0000313|RefSeq:NP_001087987.1,
GN ECO:0000313|Xenbase:XB-GENE-1012028};
GN Synonyms=agm5 {ECO:0000313|RefSeq:NP_001087987.1}, LOC494672
GN {ECO:0000313|EMBL:AAH82649.1}, lrrc8
GN {ECO:0000313|RefSeq:NP_001087987.1}, lrrc8a
GN {ECO:0000313|RefSeq:NP_001087987.1,
GN ECO:0000313|Xenbase:XB-GENE-1012028}, swell1
GN {ECO:0000313|RefSeq:NP_001087987.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH82649.1};
RN [1] {ECO:0000313|RefSeq:NP_001087987.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH82649.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH82649.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001087987.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC082649; AAH82649.1; -; mRNA.
DR RefSeq; NP_001087987.1; NM_001094518.1.
DR DNASU; 494672; -.
DR GeneID; 494672; -.
DR KEGG; xla:494672; -.
DR AGR; Xenbase:XB-GENE-1012028; -.
DR CTD; 494672; -.
DR Xenbase; XB-GENE-1012028; lrrc8a.L.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 494672; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF3; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..339
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
FT REGION 178..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 93779 MW; B9806EA4D27C2084 CRC64;
MIPVTELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMIAV FGGTLQVTQD KMICLPCKWV
THDSCNDSYR AWNAAETDFY TNSTLSPPIV PGPTGIKYDL DRHQYNYVDA VCYENRLHWF
AKYFPYLVLL HTLIFLACSN FWFKFPRTSS KLEHFVSILL KCFDSPWTTR ALSETVVEES
DPKPAGGKMN GSVDKKSSTA SEDVEATVPM LQRSKSRVEQ GIVDRSETGV LDKKEGEQAK
ALFEKVKKFR THVEEGDIVY RLYMRQTIIK VIKFIIILCY TVYYVSSIKF DVDCKVDIES
LTGYRMYRCA HPLATLFKIL ASFYISLVGF YGLVCVYTLW WMLRRSLKKY SFESIREESS
YSDIPDVKND FAFMLHLIDQ YDPLYSKRFA VFLSEVSENK LRQLNLNHEW TLDKLRQRIT
KNSQEKLELH LFMLSGIPDT VFDLVELEVL KLELIPDVTI PPSIAQLTGL KELWLYHTAA
KIEAPALAFL RENLKSLHIK FTDIKEIPLW IYSLKNLEEL HLTGNLSAEN NRYIVIDGLR
ELKRLKFLRL KSNLTKLPQV VTDVGVHLQK LSVNNEGTKL MVLNSLKKMV NLTELQLLRC
DLERIPHSIF SLHNLQEIDL KDNNLKTIEE IISFQHLHRL TCLKLWYNHI AYIPIQIGNL
ASLERLYLNR NKIEKIPTQL FLCRKLRHLD LSHNSLSSIP PEIGHLQSLQ CLAVTANHIE
NLPAELFLCK KLRTLNLGNN SLQSLPSRVG ELTNLTQMEL RGNRLEYLPV ELGDCRLLKR
SGLVVEEDLF NTLPLDVKET LSRSEKEQV
//
