ID   Q64HW5_ONCMY            Unreviewed;       673 AA.
AC   Q64HW5;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=T-cell activation Rho GTPase-activating protein {ECO:0000313|EMBL:AAU14872.1};
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022 {ECO:0000313|EMBL:AAU14872.1};
RN   [1] {ECO:0000313|EMBL:AAU14872.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Goetz F.W., Iliev D.B., Liarte C.Q., Planas J.V., MacKenzie S.;
RT   "Analysis of genes from rainbow trout macrophages.";
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY606035; AAU14872.1; -; mRNA.
DR   RefSeq; NP_001117984.1; NM_001124512.1.
DR   AlphaFoldDB; Q64HW5; -.
DR   GeneID; 100136248; -.
DR   KEGG; omy:100136248; -.
DR   OrthoDB; 2964977at2759; -.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054}.
FT   DOMAIN          88..272
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          287..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..458
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  73569 MW;  486D74194F837ABE CRC64;
     MKVLSNSITA KTLTGSGMDP FIEFPLDGGT KIPTLPKELC NAKATQPIEK GGNSKRSISI
     LRKLKRSSTL NSMSSCPDTD SKSQLFGQPL SKICPEDGML PKPITEILVL LWKKGPSTEG
     VFRTTCNNKT LKAIREQLNS GTEVEMDALP VVLLVGLLKS FLNELPGRLL VSELFETWMK
     ALESEDVHQR GLQLKRVVDK LPGPNILLLR NLLCVFHHIT MSGHANMMDA NNLAVCIAPT
     LLRKDDMTLD VQTVDKVVEL TKFLIEYCSE IFGKDILSLL GDPDEDSSES VLSQRHDSAY
     DSTDPDSEGD SMGSMQGEGG SGSSSPSLLS ACGMERGTVP SCPTNAIFHS FTNKTPFNRR
     CSEPIIFPSA GKRNLARSHD DFSVEGRDFE EQPLKKQISN DSFLLPGHGA ATRPAATLSL
     PKLDGSHPSC SSSCSLESNT SNASEGSVFT SSPLASPGCP RRAQSPHPRA DTVEVAKRRT
     QSMKVNSKAP MTTKNLGTFA RISLKKGHLQ KEKPFPCGTL QEDSQIEAEA PLRQKHPLSA
     MEAFQQVDSR LPLQPPSYEQ AVQSVAQLTL SHYGSMTVKA AAATLSRNSR PASMNANFMY
     SCTVNQYTDC FFQGTDSDDV TAVQQHSGGF RQRAMFESVS RARHETMSPH ETVSRRCSQP
     VFEEYSYAKE SYV
//