ID Q66X49_9HIV1 Unreviewed; 133 AA.
AC Q66X49;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAU06269.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAU06269.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAU06269.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Ewell M., Lathey J., Manak M.;
RT "Cultured HIV-1, Group M, Subtype A.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:2NCS, ECO:0007829|PDB:2NCT}
RP STRUCTURE BY NMR OF 95-121.
RX PubMed=27905530; DOI=10.1038/srep38177;
RA Rujas E., Caaveiro J.M., Partida-Hanon A., Gulzar N., Morante K.,
RA Apellaniz B., Garcia-Porras M., Bruix M., Tsumoto K., Scott J.K.,
RA Jimenez M.A., Nieva J.L.;
RT "Structural basis for broad neutralization of HIV-1 through the molecular
RT recognition of 10E8 helical epitope at the membrane interface.";
RL Sci. Rep. 6:38177-38177(2016).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AY699009; AAU06269.1; -; Genomic_RNA.
DR PDB; 2NCS; NMR; -; A=95-121.
DR PDB; 2NCT; NMR; -; A=95-121.
DR PDBsum; 2NCS; -.
DR PDBsum; 2NCT; -.
DR BMRB; Q66X49; -.
DR SMR; Q66X49; -.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2NCS, ECO:0007829|PDB:2NCT};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AAU06269.1};
KW Virion {ECO:0000313|EMBL:AAU06269.1}.
FT TRANSMEM 109..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..133
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAU06269.1"
FT NON_TER 133
FT /evidence="ECO:0000313|EMBL:AAU06269.1"
SQ SEQUENCE 133 AA; 15837 MW; B0F044409C101F61 CRC64;
SGGIRQLQAR VLALERYLQD QQLLGIWGCS GKLICTTTVP WNSSWSNKTY KDIWDNMTWL
EWDKEISNYT ETIYRLIEES QNQQEKNEQE LLALDKWASL WNWFDITNWL WYIKLFIMIV
GGLIGLRIVF TVL
//