ID Q68DB0_HUMAN Unreviewed; 114 AA.
AC Q68DB0;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Electrogenic sodium bicarbonate cotransporter 1 {ECO:0000256|ARBA:ARBA00039197};
DE AltName: Full=Solute carrier family 4 member 4 {ECO:0000256|ARBA:ARBA00041973};
DE Flags: Fragment;
GN Name=DKFZp781H1314 {ECO:0000313|EMBL:CAH18310.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAH18310.1};
RN [1] {ECO:0000313|EMBL:CAH18310.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Fetal kidney {ECO:0000313|EMBL:CAH18310.1};
RG The German cDNA Consortium;
RA Bloecker H., Boecher M., Brandt P., Mewes H.W., Weil B., Amid C.,
RA Osanger A., Fobo G., Han M., Wiemann S.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Electrogenic sodium/bicarbonate cotransporter with a
CC Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate
CC bicarbonate influx/efflux at the basolateral membrane of cells and
CC regulate intracellular pH. {ECO:0000256|ARBA:ARBA00037277}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 hydrogencarbonate(out) + Na(+)(out) = 2
CC hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72215,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000256|ARBA:ARBA00036309};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 hydrogencarbonate(out) + Na(+)(out) = 3
CC hydrogencarbonate(in) + Na(+)(in); Xref=Rhea:RHEA:72219,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000256|ARBA:ARBA00035820};
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DR EMBL; CR749482; CAH18310.1; -; mRNA.
DR AlphaFoldDB; Q68DB0; -.
DR PeptideAtlas; Q68DB0; -.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008510; F:sodium:bicarbonate symporter activity; IEA:UniProt.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF10; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 1; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 2: Evidence at transcript level;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transport {ECO:0000256|ARBA:ARBA00022847}.
FT DOMAIN 1..61
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT REGION 64..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAH18310.1"
SQ SEQUENCE 114 AA; 12418 MW; 70EB003E830C44E4 CRC64;
LLGPKGKAKS YHEIGRAIAT LMSDEVFHDI AYKAKDRHDL IAGIDEFLDE VIVLPPGEWD
PAIRIEPPKS LPSSDKRKNM YSGGENVQMN GDTPHDGGHG GGGHGDCEEL QQEN
//
