ID Q68WH1_RICTY Unreviewed; 594 AA.
AC Q68WH1;
DT 11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Cell division protein FtsI/ penicillin-binding protein {ECO:0000313|EMBL:AAU04021.1};
GN Name=ftsI1 {ECO:0000313|EMBL:AAU04021.1};
GN OrderedLocusNames=RT0553 {ECO:0000313|EMBL:AAU04021.1};
OS Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=257363 {ECO:0000313|EMBL:AAU04021.1, ECO:0000313|Proteomes:UP000000604};
RN [1] {ECO:0000313|EMBL:AAU04021.1, ECO:0000313|Proteomes:UP000000604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-144 / Wilmington {ECO:0000313|Proteomes:UP000000604};
RX PubMed=15317790; DOI=10.1128/JB.186.17.5842-5855.2004;
RA McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA Yu X.-J., Walker D.H., Weinstock G.M.;
RT "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT of other Rickettsiae.";
RL J. Bacteriol. 186:5842-5855(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; AE017197; AAU04021.1; -; Genomic_DNA.
DR RefSeq; WP_011191002.1; NC_006142.1.
DR AlphaFoldDB; Q68WH1; -.
DR KEGG; rty:RT0553; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_5; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000000604; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000313|EMBL:AAU04021.1};
KW Cell division {ECO:0000313|EMBL:AAU04021.1};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022676};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..229
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 262..585
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 594 AA; 66962 MW; 8647EBDAB3856C95 CRC64;
MLNKKILHGE LISRRAFIIG LGKLWFLSLL GIRMFYLQLI KSEEYRTLSD KNRINFVVLP
PIRGKIYDLD GNILATNKPC YQLVIDKSIN NNYRDELEII SNILNFSPDK YNYIKQKIKK
SSRHTILTIL DHLDWEQVSM IEEQKHKLAA IFIDVGYLRF YPFSSTTSHL IGYLGQINEQ
EKQELNIRSL SDFNIGKSGI EKYYDNKLRG EFGYKKVEVN AYGKQVRTIS ETPTQSGADM
HLNIDASLQK KIQQYLNPKG SSAIVMDIRT GNVLICVSTP GFESNNFSKL SENYWQSLIS
DPHKPLINKV IQNSYPPGSV FKIITVLAAL EVGINPNKTV FCDGSSILGT NSFRCWNHRG
HGTLDMMSAL KYSCNIYMYE LARIVGPDKI LAVAREFGFG SKTGIDISPE SSGFVPSKEW
KKKKLKLPWS IGDSFNLAIG QGFLGVTPIQ LARFITAIAS NGKLYTPRIL KNASEFYNVN
IKTENIKIIQ ESLYNTVNVA GGTAYYNRIF AENRKLAGKT GTAQVQSKLN AKDDLNRDSI
AWARRNHALF LGFAPYSDPR YSVTVFVDHG GGGSIAAAPV ARKIMSDVLD KYMR
//
