ID BZP46_ORYSJ Reviewed; 324 AA.
AC Q69TW5; E3TB03;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE RecName: Full=bZIP transcription factor 46 {ECO:0000305};
DE Short=OsBZIP46 {ECO:0000303|PubMed:18065552};
DE AltName: Full=AREB/ABF-family transcription factor 8 {ECO:0000303|PubMed:19947981};
DE Short=OsAREB8 {ECO:0000303|PubMed:19947981};
DE AltName: Full=Abscisic acid responsive elements-binding factor 2 {ECO:0000303|PubMed:20576316};
DE Short=ABRE-binding factor 2 {ECO:0000303|PubMed:20576316};
DE Short=OsABF2 {ECO:0000303|PubMed:20576316};
DE AltName: Full=Abscisic acid responsive elements-binding factor 3 {ECO:0000303|PubMed:18315698};
DE Short=ABRE-binding factor 3 {ECO:0000303|PubMed:18315698};
DE Short=OsABF3 {ECO:0000303|PubMed:18315698};
DE AltName: Full=Protein ABI5-LIKE 1 {ECO:0000303|PubMed:21546455};
GN Name=BZIP46 {ECO:0000303|PubMed:18065552};
GN Synonyms=ABF2 {ECO:0000303|PubMed:20576316},
GN ABF3 {ECO:0000303|PubMed:18315698}, ABL1 {ECO:0000303|PubMed:21546455},
GN AREB8 {ECO:0000303|PubMed:19947981};
GN OrderedLocusNames=Os06g0211200 {ECO:0000312|EMBL:BAF19032.1},
GN LOC_Os06g10880 {ECO:0000305};
GN ORFNames=P0021C04.25 {ECO:0000312|EMBL:BAD35712.1},
GN P0701E03.2 {ECO:0000312|EMBL:BAD35171.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND INDUCTION.
RX PubMed=20576316; DOI=10.1016/j.jplph.2010.05.008;
RA Hossain M.A., Cho J.I., Han M., Ahn C.H., Jeon J.S., An G., Park P.B.;
RT "The ABRE-binding bZIP transcription factor OsABF2 is a positive regulator
RT of abiotic stress and ABA signaling in rice.";
RL J. Plant Physiol. 167:1512-1520(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP INDUCTION BY ABSCISIC ACID.
RX PubMed=18315698; DOI=10.1111/j.1469-8137.2007.02365.x;
RA Shobbar Z.S., Oane R., Gamuyao R., De Palma J., Malboobi M.A.,
RA Karimzadeh G., Javaran M.J., Bennett J.;
RT "Abscisic acid regulates gene expression in cortical fiber cells and silica
RT cells of rice shoots.";
RL New Phytol. 178:68-79(2008).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18065552; DOI=10.1104/pp.107.112821;
RA Nijhawan A., Jain M., Tyagi A.K., Khurana J.P.;
RT "Genomic survey and gene expression analysis of the basic leucine zipper
RT transcription factor family in rice.";
RL Plant Physiol. 146:333-350(2008).
RN [8]
RP FUNCTION.
RX PubMed=19947981; DOI=10.1111/j.1365-313x.2009.04092.x;
RA Yoshida T., Fujita Y., Sayama H., Kidokoro S., Maruyama K., Mizoi J.,
RA Shinozaki K., Yamaguchi-Shinozaki K.;
RT "AREB1, AREB2, and ABF3 are master transcription factors that cooperatively
RT regulate ABRE-dependent ABA signaling involved in drought stress tolerance
RT and require ABA for full activation.";
RL Plant J. 61:672-685(2010).
RN [9]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=21546455; DOI=10.1104/pp.111.173427;
RA Yang X., Yang Y.N., Xue L.J., Zou M.J., Liu J.Y., Chen F., Xue H.W.;
RT "Rice ABI5-Like1 regulates abscisic acid and auxin responses by affecting
RT the expression of ABRE-containing genes.";
RL Plant Physiol. 156:1397-1409(2011).
RN [10]
RP FUNCTION, INTERACTION WITH SAPK2; SAPK6 AND SAPK9, SUBCELLULAR LOCATION,
RP INDUCTION, AND PHOSPHORYLATION.
RX PubMed=22301130; DOI=10.1104/pp.111.190389;
RA Tang N., Zhang H., Li X., Xiao J., Xiong L.;
RT "Constitutive activation of transcription factor OsbZIP46 improves drought
RT tolerance in rice.";
RL Plant Physiol. 158:1755-1768(2012).
RN [11]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=26300907; DOI=10.3389/fpls.2015.00614;
RA Kim N., Moon S.J., Min M.K., Choi E.H., Kim J.A., Koh E.Y., Yoon I.,
RA Byun M.O., Yoo S.D., Kim B.G.;
RT "Functional characterization and reconstitution of ABA signaling components
RT using transient gene expression in rice protoplasts.";
RL Front. Plant Sci. 6:614-614(2015).
RN [12]
RP FUNCTION, INTERACTION WITH MODD, AND SUBCELLULAR LOCATION.
RX PubMed=27468891; DOI=10.1105/tpc.16.00171;
RA Tang N., Ma S., Zong W., Yang N., Lv Y., Yan C., Guo Z., Li J., Li X.,
RA Xiang Y., Song H., Xiao J., Li X., Xiong L.;
RT "MODD mediates deactivation and degradation of OsbZIP46 to negatively
RT regulate ABA signaling and drought resistance in rice.";
RL Plant Cell 28:2161-2177(2016).
CC -!- FUNCTION: Transcription factor involved in abscisic acid (ABA)
CC signaling pathway (PubMed:20576316, PubMed:19947981, PubMed:21546455,
CC PubMed:22301130, PubMed:26300907, PubMed:27468891). Transcription
CC factor activity is fully activated by ABA (PubMed:19947981,
CC PubMed:26300907, PubMed:27468891). Acts as a positive regulator of the
CC expression of abiotic stress-responsive genes through an ABA-dependent
CC signaling pathway (PubMed:20576316). Acts as a positive regulator of
CC ABA signaling and drought stress tolerance (PubMed:22301130). Plays an
CC important role in ABA and auxin responses. Involved in ABA signaling
CC and stress responses by directly binding to the ABA-responsive element
CC (ABRE)-containing genes, especially WRKY family genes. Modulates
CC response to auxin. Suppresses auxin signaling by targeting ABRE-
CC containing genes related to auxin metabolism or signaling
CC (PubMed:21546455). {ECO:0000269|PubMed:19947981,
CC ECO:0000269|PubMed:20576316, ECO:0000269|PubMed:21546455,
CC ECO:0000269|PubMed:22301130, ECO:0000269|PubMed:26300907,
CC ECO:0000269|PubMed:27468891}.
CC -!- SUBUNIT: Interacts with MODD (PubMed:27468891). Interacts with SAPK2,
CC SAPK6 and SAPK9 (PubMed:22301130). {ECO:0000269|PubMed:22301130,
CC ECO:0000269|PubMed:27468891}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978,
CC ECO:0000269|PubMed:20576316, ECO:0000269|PubMed:21546455,
CC ECO:0000269|PubMed:22301130, ECO:0000269|PubMed:26300907,
CC ECO:0000269|PubMed:27468891}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, shoots, leaves, flag leaves,
CC stems, flowers and panicles (PubMed:20576316). Widely expressed
CC (PubMed:21546455). {ECO:0000269|PubMed:20576316,
CC ECO:0000269|PubMed:21546455}.
CC -!- INDUCTION: Induced by abscisic acid (ABA) (PubMed:20576316,
CC PubMed:18315698, PubMed:21546455, PubMed:22301130). Induced by auxin
CC (PubMed:21546455, PubMed:22301130). Induced by gibberellin
CC (PubMed:21546455). Induced by salt and drought stresses
CC (PubMed:20576316, PubMed:21546455, PubMed:22301130). Induced by cold
CC stress (PubMed:20576316). Induced by oxidative stress (PubMed:20576316,
CC PubMed:22301130). {ECO:0000269|PubMed:18315698,
CC ECO:0000269|PubMed:20576316, ECO:0000269|PubMed:21546455,
CC ECO:0000269|PubMed:22301130}.
CC -!- PTM: Phosphorylated on serine and threonine residues by SAPK2, SAPK6
CC and SAPK9. Phosphorylation is required for full transactivation
CC activity. {ECO:0000269|PubMed:22301130}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant plants exhibit increased sensitivity to salt and
CC drought stresses (PubMed:20576316). Decreased sensitivity to abscisic
CC acid (ABA) (PubMed:20576316, PubMed:21546455).
CC {ECO:0000269|PubMed:20576316, ECO:0000269|PubMed:21546455}.
CC -!- MISCELLANEOUS: Plants over-expressing BZIP46 display increased
CC sensitivity to abscisic acid (ABA). {ECO:0000269|PubMed:22301130}.
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DR EMBL; GU552783; ADK60888.1; -; mRNA.
DR EMBL; AP003458; BAD35171.1; -; Genomic_DNA.
DR EMBL; AP004687; BAD35712.1; -; Genomic_DNA.
DR EMBL; AP008212; BAF19032.1; -; Genomic_DNA.
DR EMBL; AP014962; BAS96743.1; -; Genomic_DNA.
DR EMBL; AK103188; BAG95943.1; -; mRNA.
DR EMBL; AK105312; BAG97190.1; -; mRNA.
DR RefSeq; XP_015640996.1; XM_015785510.1.
DR AlphaFoldDB; Q69TW5; -.
DR SMR; Q69TW5; -.
DR STRING; 39947.Q69TW5; -.
DR PaxDb; 39947-Q69TW5; -.
DR EnsemblPlants; Os06t0211200-01; Os06t0211200-01; Os06g0211200.
DR EnsemblPlants; Os06t0211200-02; Os06t0211200-02; Os06g0211200.
DR GeneID; 4340462; -.
DR Gramene; Os06t0211200-01; Os06t0211200-01; Os06g0211200.
DR Gramene; Os06t0211200-02; Os06t0211200-02; Os06g0211200.
DR KEGG; osa:4340462; -.
DR eggNOG; ENOG502QPP6; Eukaryota.
DR HOGENOM; CLU_043238_1_0_1; -.
DR InParanoid; Q69TW5; -.
DR OMA; REDNTQF; -.
DR OrthoDB; 403439at2759; -.
DR PlantReactome; R-OSA-3899351; Abscisic acid (ABA) mediated signaling.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009789; P:positive regulation of abscisic acid-activated signaling pathway; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IDA:UniProtKB.
DR GO; GO:0009651; P:response to salt stress; IMP:UniProtKB.
DR GO; GO:0009414; P:response to water deprivation; IMP:UniProtKB.
DR CDD; cd14707; bZIP_plant_BZIP46; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR043452; BZIP46-like.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR22952:SF484; BZIP TRANSCRIPTION FACTOR 46; 1.
DR PANTHER; PTHR22952; CAMP-RESPONSE ELEMENT BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW Abscisic acid signaling pathway; DNA-binding; Nucleus; Reference proteome;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..324
FT /note="bZIP transcription factor 46"
FT /id="PRO_0000440559"
FT DOMAIN 242..287
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 106..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..263
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 270..284
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 324 AA; 34688 MW; C2B67BA7C75B5EB8 CRC64;
MELPADGSAL ARQGSIYSLT FDEFQSALGS AEKDFGSMNM DELLRNIWTA EESQAIAPAA
AAASAAAVVG DAQQQQQPIQ RQGSLTLPRT LSQKTVDEVW RDIMGLGGSD DEDPAAAAAA
AAPAQRQPTL GEMTLEEFLV RAGVVREDMG QTIVLPPQAQ ALFPGSNVVA PAMQLANGML
PGVVGVAPGA AAAMTVAAPA TPVVLNGLGK VEGGDLSSLS PVPYPFDTAL RVRKGPTVEK
VVERRQRRMI KNRESAARSR ARKQAYIMEL EAEVAKLKEQ KAELQKKQVE MIQKQNDEVM
ERITQQLGPK AKRFCLRRTL TGPC
//
