ID HBAP1_DANRE Reviewed; 449 AA.
AC Q6AXL5; B0S6T4;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=HSPB1-associated protein 1 homolog;
GN Name=hspbap1; ORFNames=si:dkey-25l23.5, zgc:100975;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in cellular stress response. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; BX548071; CAQ14575.1; -; Genomic_DNA.
DR EMBL; BC079489; AAH79489.1; -; mRNA.
DR RefSeq; NP_001003777.1; NM_001003777.2.
DR AlphaFoldDB; Q6AXL5; -.
DR SMR; Q6AXL5; -.
DR STRING; 7955.ENSDARP00000039912; -.
DR PaxDb; 7955-ENSDARP00000039912; -.
DR GeneID; 445320; -.
DR KEGG; dre:445320; -.
DR AGR; ZFIN:ZDB-GENE-040808-38; -.
DR CTD; 79663; -.
DR ZFIN; ZDB-GENE-040808-38; hspbap1.
DR eggNOG; KOG2132; Eukaryota.
DR HOGENOM; CLU_016785_5_1_1; -.
DR InParanoid; Q6AXL5; -.
DR OrthoDB; 5401772at2759; -.
DR PhylomeDB; Q6AXL5; -.
DR TreeFam; TF315056; -.
DR PRO; PR:Q6AXL5; -.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000033771; Expressed in ovary and 21 other cell types or tissues.
DR ExpressionAtlas; Q6AXL5; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; IBA:GO_Central.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR003347; JmjC_dom.
DR PANTHER; PTHR12461:SF43; HSPB1-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR12461; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED; 1.
DR Pfam; PF13621; Cupin_8; 1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..449
FT /note="HSPB1-associated protein 1 homolog"
FT /id="PRO_0000284116"
FT DOMAIN 102..266
FT /note="JmjC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT REGION 385..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 47
FT /note="K -> E (in Ref. 2; AAH79489)"
FT /evidence="ECO:0000305"
FT CONFLICT 92..94
FT /note="PFL -> AFS (in Ref. 2; AAH79489)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="V -> A (in Ref. 2; AAH79489)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="E -> Q (in Ref. 2; AAH79489)"
FT /evidence="ECO:0000305"
FT CONFLICT 408..409
FT /note="EN -> GS (in Ref. 2; AAH79489)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 50992 MW; D766238840994B3C CRC64;
MSSKPFTPEE ARRIVQVLQK PAVFLNMTTD WPALHWTVEH LSACLTKRIR FRVGKRSEDM
APLFETECSY VEATIKEFLS WTANDGEPLV GPFLDYHCKE FWAYADYKYI AQLFQDKPAM
FQDVVWSDFG FPGRDGRDST LWIGTQCANT PCHLDSYGCN LVFQIQGRKR WHLFPPDDTA
CLYPTRVPYE ESSVFSHVNV IRPDLKKFPA YGRARLYTVT LQPGQVLFVP RHWWHYVESV
DPVTVSVNSW IEMDMDDEAR VAEALTKTIV CAVKSSPSLD NSDQWLNPTE DGVSSHDENM
QYLNLAVKVC MNKKRDDIED QPKAEAVKRD FSGVLKSPAS PPSLVSFGPH LIPVHLTEKP
QCSSTKDSCC FSCTDSPQCQ ITTKDQDKLR SDNKLGQRSG QSVLQDTENP GGSGEMHIST
NDVLECLVHP DVIALVTRLI MCRQRELHS
//
